间充质基质细胞（MSC）是肿瘤基质的重要细胞成分，在肿瘤发展中发挥积极作用。间充质干细胞和癌症之间复杂的相互作用通过为肿瘤细胞增殖、血管生成、运动、侵袭和转移创造有利的环境来促进肿瘤进展。间充质干细胞的细胞异质性、来源、分离方法、培养技术和模型系统的多样性，以及不同的肿瘤亚型，增加了间充质干细胞与肿瘤相互作用的复杂性。在这篇综述中，我们讨论了 MSC 介导的肿瘤促进机制，并评估了癌细胞、MSC、肿瘤微环境 (TME) 细胞和细胞外基质 (ECM) 之间的细胞-基质相互作用。对肿瘤与间充质干细胞相互作用的更全面了解可能会带来更好的癌症管理。© 2024。作者。

Mesenchymal stromal cells (MSCs) are important cellular constituents of tumor stroma that play an active role in tumor development. Complex interactions between MSCs and cancer promote tumor progression by creating a favorable milieu for tumor cell proliferation, angiogenesis, motility, invasion, and metastasis. The cellular heterogeneity, source of origin, diversity in isolation methods, culture techniques and model systems of MSCs, together with the different tumor subtypes, add to the complexity of MSC-tumor interactions. In this review, we discuss the mechanisms of MSC-mediated tumor promotion and evaluate cell-stromal interactions between cancer cells, MSCs, cells of the tumor microenvironment (TME), and the extracellular matrix (ECM). A more thorough understanding of tumor-MSC interactions is likely to lead to better cancer management.© 2024. The Author(s).