本研究检查了副肿瘤综合征中口腔体征和症状的患病率。从开始到 2024 年 4 月 1 日，在 MEDLINE/PubMed、Ovid 和 Scopus 数据库中对口腔副肿瘤综合征进行了系统检索。使用 MURAD 或进行了预后研究工具的质量和随机效应荟萃分析。使用 GRADE 方法对证据质量进行评级。研究样本包括来自 487 项研究的 811 名参与者。口腔表现主要影响副肿瘤性天疱疮、粘膜类天疱疮和黑棘皮症患者。腭是最常受影响的部位（18.2%；95% CI 14.7-21.9），而糜烂是与潜在恶性肿瘤相关的最常见病变类型（83.3%；95% CI 72.2-92.0）。副肿瘤综合征患者的死亡率为 50.9% (95% CI 39.9-61.7)，而肿瘤治疗后缓解率为 63.4% (95% CI 49.9-76.0)。 GRADE 评估显示所有研究结果的确定性均从低到极低。需要进一步研究以了解这些口腔表现背后的机制，这对于早期副肿瘤综合征诊断和最佳患者管理至关重要。PROSPERO 编号：CRD42022328921。© 2024 John Wiley

This study examined the prevalence of oral signs and symptoms in paraneoplastic syndromes.A systematic search on oral paraneoplastic syndromes was conducted in MEDLINE/PubMed, Ovid, and Scopus databases from inception to April 1, 2024. Risk of bias was evaluated using the MURAD or Quality in Prognosis Studies tools, and a random-effects meta-analysis was performed. Evidence quality was rated using the GRADE approach.The study sample comprised 811 participants from 487 studies. Oral manifestations predominantly affected patients with paraneoplastic pemphigus, mucous membrane pemphigoid, and acanthosis nigricans. Palate is the most frequently affected site (18.2%; 95% confidence interval [CI] 14.7-21.9), while erosion was the most common lesion type (83.3%; 95% CI 72.2-92.0) associated with the underlying malignancy. The prevalence of death in people with paraneoplastic syndromes was 50.9% (95% CI 39.9-61.7), while the prevalence of remission after neoplasm treatment was 63.4% (95% CI 49.9-76.0). GRADE assessment revealed uniformly low to very low certainty for all outcomes studied.Further research is needed to understand the mechanisms behind these oral manifestations, which is crucial for earlier paraneoplastic syndrome diagnosis and optimal patient management.PROSPERO number: CRD42022328921.© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.