副塑性综合征的口服表现：系统评价和荟萃分析
Oral Manifestations in Paraneoplastic Syndromes: A Systematic Review and Meta-Analysis
影响因子:2.90000
分区:医学3区 / 牙科与口腔外科4区
发表日期:2025 Jan
作者:
Sabrina Messina, Domenico De Falco, Massimo Petruzzi
摘要
这项研究检查了副塑性综合征中口腔体征和症状的患病率。在Medline/PubMed，OVID，OVID和Scopus数据库中进行了系统的口腔副塑性综合征进行系统的搜索，从Inception到2024年4月1日，使用偏见的风险进行了预测工具，并进行了预测的工具，并进行了一种偏见的风险。使用等级方法对证据质量进行了评估。该研究样本包括来自487个研究的811名参与者。口服表现主要影响患有副塑性孢子，粘膜刺激性和阿斯纳斯病的患者。口感是受影响最常的部位（18.2％； 95％置信区间[CI] 14.7-21.9），而侵蚀是最常见的病变类型（83.3％； 95％CI 72.2-92.0）。副肿瘤综合征患者的死亡率为50.9％（95％CI 39.9-61.7），而肿瘤治疗后的缓解率为63.4％（95％CI 49.9-76.0）。年级评估显示，对所研究的所有结果均均匀至非常低的确定性。需要研究以了解这些口服表现背后的机制，这对于早期的副塑料综合征诊断和最佳患者管理至关重要。
Abstract
This study examined the prevalence of oral signs and symptoms in paraneoplastic syndromes.A systematic search on oral paraneoplastic syndromes was conducted in MEDLINE/PubMed, Ovid, and Scopus databases from inception to April 1, 2024. Risk of bias was evaluated using the MURAD or Quality in Prognosis Studies tools, and a random-effects meta-analysis was performed. Evidence quality was rated using the GRADE approach.The study sample comprised 811 participants from 487 studies. Oral manifestations predominantly affected patients with paraneoplastic pemphigus, mucous membrane pemphigoid, and acanthosis nigricans. Palate is the most frequently affected site (18.2%; 95% confidence interval [CI] 14.7-21.9), while erosion was the most common lesion type (83.3%; 95% CI 72.2-92.0) associated with the underlying malignancy. The prevalence of death in people with paraneoplastic syndromes was 50.9% (95% CI 39.9-61.7), while the prevalence of remission after neoplasm treatment was 63.4% (95% CI 49.9-76.0). GRADE assessment revealed uniformly low to very low certainty for all outcomes studied.Further research is needed to understand the mechanisms behind these oral manifestations, which is crucial for earlier paraneoplastic syndrome diagnosis and optimal patient management.PROSPERO number: CRD42022328921.