25-羟基维生素D是人体维生素D的主要储存形式，是国际上公认的反映人体内维生素D状况的最佳指标。缺乏研究调查老年高脂血症患者血清 25-羟基维生素 D (25(OH)D) 水平与死亡率之间的相互关系。为了解决这一知识差距，我们研究了 NHANES 老年高脂血症人群的血清 25(OH)D 水平与死亡率之间的关联，同时控制了其他影响因素。该研究旨在阐明血清 25(OH)D 水平与全因死亡率、心血管疾病 (CVD)、恶性肿瘤和其他原因死亡率之间的相关性。数据来自 NHANES 2001-2016 年，包括 9,271 名参与者分析以检查血清 25(OH)D 水平与死亡率之间的关联。使用 Kaplan-Meier 曲线和限制三次样条说明了相互关系，同时利用 Cox 比例风险模型来估计多因素调整风险比 (HR)。 这项研究包括 9,271 名参与者（43.28% 男性），平均年龄为 69.58 岁，参与者的平均随访时间为 88.37 个月。 Kaplan-Meier 曲线表明，较低的血清 25(OH)D 水平与全因死亡、心血管死亡、恶性肿瘤死亡和其他原因死亡的风险增加相关。 Cox 比例风险模型进一步证实了这种负相关性。此外，受限三次样条不仅揭示了这种负相关性，而且还突出了饱和血清 25(OH)D 水平。此外，亚组分析表明，血清 25(OH)D 水平与全因死亡率之间的负相关性在非肥胖和吸烟人群中更为明显。在非肥胖人群中，与其他原因死亡率的负相关性更强。在患有高脂血症的老年人群中，25(OH)D血清水平与特定原因死亡率和全因死亡率均呈负相关。而且，这种负关联还存在阈值效应。版权所有 © 2024 潘、张、孙、史、张。

25-hydroxyvitamin D is the body's main storage form of vitamin D and is internationally recognized as the best indicator of vitamin D status in the human body. There is a scarcity of research investigating the interrelationship between serum 25-hydroxyvitamin D (25(OH)D) levels and mortality among elderly individuals with hyperlipidemia. To address this knowledge gap, we examined the association between serum 25(OH)D levels and mortality in an older hyperlipidemic population from NHANES, while controlling for other influential factors. The study sought to elucidate the correlation between serum 25(OH)D levels and mortality about all-cause mortality, cardiovascular disease (CVD), malignant neoplasms, and mortality from other causes.The data from NHANES 2001-2016, including 9,271 participants were analyzed to examine the association between serum 25(OH)D levels and mortality. The interrelationship was illustrated using Kaplan-Meier curves and restricted cubic splines, while the Cox proportional hazards model was utilized to estimate the multifactor adjusted hazard ratio (HR).This study included 9,271 participants (43.28% male) with an average age of 69.58 years, and the average duration of participant follow-up was 88.37 months. Kaplan-Meier curves demonstrated that lower serum 25(OH)D levels were associated with increased risks of all-cause mortality, cardiovascular mortality, malignant neoplasm mortality, and mortality from other causes. This negative association was further confirmed by the Cox proportional hazards models. Additionally, restricted cubic splines not only revealed this negative association but also highlighted the saturated serum 25(OH)D levels. Moreover, subgroup analyses indicated that the inverse correlation between serum 25(OH)D levels and all-cause mortality was more pronounced in the non-obese and smoking population. And the inverse correlation with mortality from other causes was even stronger in the non-obese population.In the elderly population with hyperlipidemia, 25(OH)D serum levels were negatively correlated with both cause-specific mortality and all-cause mortality. Moreover, there was a threshold effect in this negative association.Copyright © 2024 Pan, Zhang, Sun, Shi and Zhang.