血清25-羟基维生素D水平与死亡率的血清之间的饱和关联：高脂血症：NHANES的一项基于人群的研究（2001- 2016年）

25-羟基维生素D是体内维生素D的主要储存形式，在国际上被认为是人体维生素D状态的最佳指标。研究研究血清25-羟基维生素D（25（OH）D）水平和死亡率之间的相互关系缺乏研究。为了解决这一知识差距，我们研究了NHANES较旧的高脂血症人群中血清25（OH）D水平与死亡率之间的关联，同时控制了其他影响因素。该研究旨在阐明血清25（OH）D水平与全因死亡率，心血管疾病（CVD），恶性肿瘤和其他原因的死亡率之间的相关性。NHANES 2001-2016的数据分析了9,271名参与者，包括9,271名参与者，以检查血清之间的协会之间的相关性25（OH）25（OH）之间。使用Kaplan-Meier曲线和限制的立方花纹进行了相互关系，而COX比例危害模型被用于估计多因素调整危险比（HR）。这项研究包括9,271名参与者（男性为43.28％）（男性为43.28％），平均年龄为69.58岁，平均参与时间为69.58个月。 Kaplan-Meier曲线表明，较低的血清25（OH）D水平与全因死亡率，心血管死亡率，恶性肿瘤死亡率以及其他原因的死亡率增加有关。 COX比例危害模型进一步证实了这种负相关。此外，受限制的立方花纹不仅揭示了这种负相关性，而且还强调了饱和血清25（OH）D水平。此外，亚组分析表明，血清25（OH）D水平与全因死亡率之间的反相关性在非肥胖和吸烟人群中更为明显。在非肥胖人群中，与其他原因的死亡率相关性甚至更强。此外，这种负相关性具有阈值效应。

25-hydroxyvitamin D is the body's main storage form of vitamin D and is internationally recognized as the best indicator of vitamin D status in the human body. There is a scarcity of research investigating the interrelationship between serum 25-hydroxyvitamin D (25(OH)D) levels and mortality among elderly individuals with hyperlipidemia. To address this knowledge gap, we examined the association between serum 25(OH)D levels and mortality in an older hyperlipidemic population from NHANES, while controlling for other influential factors. The study sought to elucidate the correlation between serum 25(OH)D levels and mortality about all-cause mortality, cardiovascular disease (CVD), malignant neoplasms, and mortality from other causes.The data from NHANES 2001-2016, including 9,271 participants were analyzed to examine the association between serum 25(OH)D levels and mortality. The interrelationship was illustrated using Kaplan-Meier curves and restricted cubic splines, while the Cox proportional hazards model was utilized to estimate the multifactor adjusted hazard ratio (HR).This study included 9,271 participants (43.28% male) with an average age of 69.58 years, and the average duration of participant follow-up was 88.37 months. Kaplan-Meier curves demonstrated that lower serum 25(OH)D levels were associated with increased risks of all-cause mortality, cardiovascular mortality, malignant neoplasm mortality, and mortality from other causes. This negative association was further confirmed by the Cox proportional hazards models. Additionally, restricted cubic splines not only revealed this negative association but also highlighted the saturated serum 25(OH)D levels. Moreover, subgroup analyses indicated that the inverse correlation between serum 25(OH)D levels and all-cause mortality was more pronounced in the non-obese and smoking population. And the inverse correlation with mortality from other causes was even stronger in the non-obese population.In the elderly population with hyperlipidemia, 25(OH)D serum levels were negatively correlated with both cause-specific mortality and all-cause mortality. Moreover, there was a threshold effect in this negative association.