肽基脯氨酰顺/反异构酶 NIMA-相互作用 1 (Pin1) 催化脯氨酸环从顺式构象转变为反式构象，导致蛋白质构象和功能发生变化，这些变化受脯氨酸引导的丝氨酸/苏氨酸磷酸化的调节。近年来，Pin1已成为诊断和治疗多种恶性肿瘤的新型分子靶点。值得注意的是，研究发现Pin1在胰腺癌中高表达。本文重点介绍 Pin1 在胰腺癌发生过程中协调多种致癌功能的机制。通过探索 Pin1 与胰腺肿瘤微环境之间复杂的相互作用，我们概述了 Pin1 在改变胰腺癌的糖酵解代谢、氧化还原平衡和缺氧微环境中的作用。此外，我们总结了 Pin1 抑制剂的潜在抗癌作用，旨在阐明 Pin1 作为潜在抗癌药物的前景，特别是在胰腺癌的背景下。版权所有 © 2024 Elsevier Inc. 保留所有权利。

The peptidyl-prolyl cis/trans isomerase NIMA-interaction 1 (Pin1) catalyzes the transition of the proline ring from the cis to trans conformation, resulting in conformational and functional changes in proteins that are regulated by proline-guided serine/threonine phosphorylation. In recent years, Pin1 has emerged as a novel molecular target for the diagnosis and treatment of various malignant tumors. Notably, it has been found that Pin1 is highly expressed in pancreatic cancer. This article focuses on the mechanisms by which Pin1 orchestrates multiple oncogenic functions in the development of pancreatic cancer. By exploring the intricate interactions between Pin1 and the pancreatic tumor microenvironment, we provide an overview of Pin1's role in modifying glycolytic metabolism, redox balance, and the hypoxic microenvironment of pancreatic cancer. Furthermore, we summarize the potential anticancer effects of Pin1 inhibitors, aiming to elucidate Pin1's promise as a potential anticancer agent, particularly in the context of pancreatic cancer.Copyright © 2024 Elsevier Inc. All rights reserved.