结直肠癌（CRC），位居全球第三大恶性肿瘤。尽管治疗方法取得了进步，但对于处于疾病晚期的患者来说，死亡率仍然高得令人痛苦。铁死亡是细胞死亡的一种程序性形式。铁死亡的途径主要包括促进细胞ROS的积累和增加细胞不稳定铁池（LIP）的水平。免疫衰老的特征是免疫系统响应病原体和维持对癌细胞的监视的能力逐渐恶化。在结直肠癌中，肿瘤微环境会加剧这种下降，肿瘤微环境可以抑制免疫反应并促进肿瘤进展。本文对结直肠癌铁脱垂与免疫衰老的关系进行综述，重点研究以下几个方面：一是引起结直肠癌铁脱垂的不同途径；其次，结直肠癌中的免疫-免疫衰老；最后，结直肠癌中免疫衰老和铁脱垂之间的相互作用，例如，免疫免疫衰老细胞通常表现出氧化应激增加，导致ROS积累，从而导致脂质过氧化并诱导铁诱导的细胞死亡。同时，铁死亡通过促进受损或患病细胞的死亡并导致通常与之相关的炎症来诱导免疫细胞衰老以及免疫微环境的改变。总之，通过探索铁死亡和免疫衰老在结直肠癌治疗中的潜在靶点，我们希望为未来的研究提供参考。版权所有©2024。由Elsevier Ltd.出版。

Colorectal cancer (CRC), ranked as the globe's third leading malignancy. Despite advancements in therapeutic approaches, the mortality rate remains distressingly high for those afflicted with advanced stages of the disease. Ferroptosis is a programmed form of cell death. The ways of ferroptosis mainly include promoting the accumulation of cellular ROS and increasing the level of cellular Labile iron pool (LIP). Immunosenescence is characterized by a gradual deterioration of the immune system's ability to respond to pathogens and maintain surveillance against cancer cells. In CRC, this decline is exacerbated by the tumor microenvironment, which can suppress the immune response and promote tumor progression. This paper reviews the relationship between iron prolapse and immune senescence in colorectal cancer, focusing on the following aspects: firstly, the different pathways that induce iron prolapse in colorectal cancer; secondly, immune-immune senescence in colorectal cancer; and lastly, the interactions between immune senescence and iron prolapse in colorectal cancer, e.g., immune-immune senescent cells often exhibit increased oxidative stress, leading to the accumulation of ROS, and consequently to lipid peroxidation and induction of iron-induced cell death. At the same time, ferroptosis induces immune cell senescence as well as alterations in the immune microenvironment by promoting the death of damaged or diseased cells and leading to the inflammation usually associated with it. In conclusion, by exploring the potential targets of ferroptosis and immune senescence in colorectal cancer therapy, we hope to provide a reference for future research.Copyright © 2024. Published by Elsevier Ltd.