机器人与腹腔镜胃癌切除术:68,755 名患者的最大系统评价和荟萃分析。
Robotic Versus Laparoscopic Gastrectomy for Gastric Cancer: The Largest Systematic Reviews of 68,755 Patients and Meta-analysis.
发表日期:2024 Oct 17
作者:
Rui Du, Yue Wan, Yulong Shang, Guofang Lu
来源:
ANNALS OF SURGICAL ONCOLOGY
摘要:
这项荟萃分析旨在比较机器人胃切除术 (RG) 和腹腔镜胃切除术 (LG) 在治疗胃癌 (GC) 中的疗效。对 PubMed、MEDLINE 和 Web of Science 进行的综合文献检索确定了 86 项符合条件的研究,其中包括 68,755 名患者(RG 组有 20,894 例,LG 组有 47,861 例)。分析显示,RG 在几个方面与优异的结局相关:收获更多的淋巴结、术中失血量减少、术后住院时间更短以及恢复时间更短。首次排气和经口摄入量均缩短(均 p < 0.001)。此外,RG 导致中转开放手术 (OR = 0.62,p = 0.004)、再次手术 (OR = 0.68,p = 0.010)、总体术后并发症 (OR = 0.82,p < 0.001)、严重并发症 (OR = 0.65,p < 0.001)和胰腺并发症(OR = 0.60,p = 0.004)。然而,RG 的手术时间较长,成本较高(均 p < 0.001)。 RG和LG在切缘距离、死亡率、吻合口瘘或复发率方面没有发现显着差异。RG对于GC患者来说是一种安全有效的手术选择,但需要进一步改善手术时间和费用。© 2024.肿瘤外科学会。
This meta-analysis aimed to compare the efficacy of robotic gastrectomy (RG) and laparoscopic gastrectomy (LG) in treating gastric cancer (GC).A comprehensive literature search across PubMed, MEDLINE, and Web of Science identified 86 eligible studies, including 68,755 patients (20,894 in the RG group and 47,861 in the LG group).The analysis revealed that RG was associated with superior outcomes in several areas: more lymph nodes were harvested, intraoperative blood loss was reduced, postoperative hospital stays were shorter, and the time to first flatus and oral intake was shortened (all p < 0.001). Additionally, RG resulted in lower incidences of conversion to open surgery (OR = 0.62, p = 0.004), reoperation (OR = 0.68, p = 0.010), overall postoperative complications (OR = 0.82, p < 0.001), severe complications (OR = 0.65, p < 0.001), and pancreatic complications (OR = 0.60, p = 0.004). However, RG had longer operative times and higher costs (both p < 0.001). No significant differences were found between RG and LG in terms of resection margin distance, mortality, anastomotic leakage, or recurrence rates.RG is a safe and effective surgical option for patients of GC, but further improvements in operative duration and costs are needed.© 2024. Society of Surgical Oncology.