精氨酸酶和精氨酸在免疫中的作用
The roles of arginases and arginine in immunity
影响因子:60.90000
分区:医学1区 Top / 免疫学1区
发表日期:2025 Apr
作者:
Stefania Canè, Roger Geiger, Vincenzo Bronte
摘要
免疫细胞中精氨酸酶活性和精氨酸代谢对健康和疾病具有重要的后果。它们的失调通常在癌症，自身免疫性疾病和传染病中观察到。遵循精氨酸酶在安装抗肿瘤反应的T细胞功能障碍中的作用的最初描述，许多研究扩大了我们对精氨酸酶调节和表达的理解及其与其他代谢途径的整合。在这里，我们重点介绍了精氨酸酶隔室化和人类与啮齿动物之间的储存差异，这些差异在评估精氨酸酶活性的作用时应考虑到这些差异。我们详细介绍了精氨酸酶，精氨酸及其代谢物在免疫细胞中的作用及其在癌症，自身免疫性和传染病的背景下的作用。最后，我们探索针对精氨酸酶和精氨酸的潜在治疗策略。
Abstract
Arginase activity and arginine metabolism in immune cells have important consequences for health and disease. Their dysregulation is commonly observed in cancer, autoimmune disorders and infectious diseases. Following the initial description of a role for arginase in the dysfunction of T cells mounting an antitumour response, numerous studies have broadened our understanding of the regulation and expression of arginases and their integration with other metabolic pathways. Here, we highlight the differences in arginase compartmentalization and storage between humans and rodents that should be taken into consideration when assessing the effects of arginase activity. We detail the roles of arginases, arginine and its metabolites in immune cells and their effects in the context of cancer, autoimmunity and infectious disease. Finally, we explore potential therapeutic strategies targeting arginases and arginine.