Parvimonas Micra在结直肠癌患者的患者中形成了一个独特的细菌网络
Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients
影响因子:7.50000
分区:医学2区 Top / 医学：研究与实验2区
发表日期:2024 Oct 17
作者:
Thyra Löwenmark, Linda Köhn, Therese Kellgren, William Rosenbaum, Vicky Bronnec, Anna Löfgren-Burström, Carl Zingmark, Pär Larsson, Michael Dahlberg, Bjoern O Schroeder, Sun Nyunt Wai, Ingrid Ljuslinder, Sofia Edin, Richard Palmqvist
摘要
越来越多的证据表明，肠道菌群在结直肠癌（CRC）的发展和发展中起着重要作用。特别是，口腔病原体的过度代表与CRC有关。这项研究的目的是进一步研究CRC患者的粪便微生物景观，重点是口腔病原体MICRA和核细菌核细菌。在这项研究中，使用CRC患者的粪便患者（N = 275）（N = 275）进行了16S rRNA测序（n = 95）（N = 95）。位置和微卫星不稳定性（MSI）状态，具有MISI肿瘤患者的Micra，F。nucleatum和Peptoptopoccoccussatomatis的状态更为丰富。此外，P. micra和F. nucleatum与包括CRC相关的细菌以及包括菌群菌群以及其他口服病原体（如石膏p。stomatis和各种卟啉念珠菌物种）有关。该簇在对照组中明显不同，表明其与CRC的潜在联系。您的结果表明，在CRC患者中，几种与CRC相关的细菌的分布相似，强调了考虑细菌物种在研究CRC发育机制的研究中的重要性。
Abstract
Mounting evidence suggests a significant role of the gut microbiota in the development and progression of colorectal cancer (CRC). In particular, an over-representation of oral pathogens has been linked to CRC. The aim of this study was to further investigate the faecal microbial landscape of CRC patients, with a focus on the oral pathogens Parvimonas micra and Fusobacterium nucleatum.In this study, 16S rRNA sequencing was conducted using faecal samples from CRC patients (n = 275) and controls without pathological findings (n = 95).We discovered a significant difference in microbial composition depending on tumour location and microsatellite instability (MSI) status, with P. micra, F. nucleatum, and Peptostreptococcus stomatis found to be more abundant in patients with MSI tumours. Moreover, P. micra and F. nucleatum were associated with a cluster of CRC-related bacteria including Bacteroides fragilis as well as with other oral pathogens such as P. stomatis and various Porphyromonas species. This cluster was distinctly different in the control group, suggesting its potential linkage with CRC.Our results suggest a similar distribution of several CRC-associated bacteria within CRC patients, underscoring the importance of considering the concomitant presence of bacterial species in studies investigating the mechanisms of CRC development and progression.