美国超过 10% 的成年人患有 2 型糖尿病 (DM)，其缺血性心脏病的患病率是非糖尿病患者的 2-4 倍。尽管限制这种危及生命的病症的广泛研究方法已被证明是不成功的，但这凸显了了解潜在分子机制的必要性。长非编码 RNA (lncRNA) 通过充当信号、诱饵、引导或支架来调节基因表达，与多种心血管疾病有关。然而，它们在糖尿病缺血性心脏病中的作用仍知之甚少。我们提供了关于 DM 小鼠缺血性心脏病后 lncRNA 表达谱的新见解。我们对经过假手术或 MI 手术的明确表征的 2 型 DM 模型 db/db 小鼠或其对照 db/ 进行了无偏 RNA 测序。对这些 LV 组织的 RNA 测序进行计算分析，发现了几种差异表达的 lncRNA（db/db sham 与 db/db MI），包括 Gm19522 和 Gm8075。 lncRNA Gm-19522 可能通过 DNA 蛋白激酶调节 DNA 复制，而 lncRNA Gm-8075 与癌症基因失调和 PI3K/Akt 通路相关。因此，MI 后 lncRNA Gm19522 和 Gm8075 的下调可能作为潜在的生物标志物或新的治疗靶点，以改善糖尿病缺血性心脏病的心脏修复/恢复。© 2024。作者。

More than 10% of adults in the United States have type 2 diabetes mellitus (DM) with a 2-4 times higher prevalence of ischemic heart disease than the non-diabetics. Despite extensive research approaches to limit this life-threatening condition have proven unsuccessful, highlighting the need for understanding underlying molecular mechanisms. Long noncoding RNAs (lncRNAs), which regulate gene expression by acting as signals, decoys, guides, or scaffolds have been implicated in diverse cardiovascular conditions. However, their role in ischemic heart disease in DM remains poorly understood. We provide new insights into the lncRNA expression profile after ischemic heart disease in DM mice. We performed unbiased RNA sequencing of well-characterized type 2 DM model db/db mice or its control db/+ subjected to sham or MI surgery. Computational analysis of the RNA sequencing of these LV tissues identified several differentially expressed lncRNAs between (db/db sham vs. db/db MI) including Gm19522 and Gm8075. lncRNA Gm-19522 may regulate DNA replication via DNA protein kinases, while lncRNA Gm-8075 is associated with cancer gene dysregulation and PI3K/Akt pathways. Thus, the downregulation of lncRNAs Gm19522 and Gm8075 post-MI may serve as potential biomarkers or novel therapeutic targets to improve cardiac repair/recovery in diabetic ischemic heart disease.© 2024. The Author(s).