改善功能性口服摄入和运动训练减缓食管癌患者化疗放疗后有氧能力的下降
Improved functional oral intake and exercise training attenuate decline in aerobic capacity following chemoradiotherapy in patients with esophageal cancer
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影响因子:2.3
分区:医学4区 / 康复医学3区 运动科学4区
发表日期:2024 Oct 18
作者:
Shu-Chun Huang, Lan-Yan Yang, Yin-Kai Chao, Wei-Yang Chang, Ya-Tzu Tsao, Chuan-Yi Chou, Ching-Chung Hsiao, Chien-Hung Chiu
DOI:
10.2340/jrm.v56.25906
摘要
为研究化疗放疗对食管癌患者身体健康的影响及其影响的临床因素，成功完成本研究的共有67名参与者，其中18名参与者在医院接受中等强度的有氧训练，至少进行20次。评估指标包括心肺运动试验、握力、通过生物电阻抗分析测定的身体成分、患者自评的主观全球评估、白蛋白水平以及功能性口服摄入量量表（FOIS），在化疗放疗前和完成后6-8周进行评估。在参与者中，心肺功能、握力和BC-BIA的相角在治疗过程中有所下降。化疗前后，V̇O2peak分别为19.6±4.4和17.4±3.9 mL/min/kg。在化疗过程中，FOIS的改善与有氧能力的变化呈正相关。此外，运动训练有助于减缓有氧能力的下降。食管癌患者在接受化疗放疗后，身体健康状况出现恶化。改善吞咽困难有助于维持有氧能力，运动训练则具有减缓能力下降的潜力。这一发现为提升食管癌患者的整体护理提供了参考依据。
Abstract
To investigate the impact of chemoradiotherapy on the physical fitness of patients with oesophageal cancer, and the clinical factors influencing it.A total of 67 participants successfully completed the study, with 18 of them engaging in supervised, in-hospital aerobic training at moderate intensity for a minimum of 20 sessions. Cardiopulmonary exercise testing, hand grip strength, body composition assessed via bioelectrical impedance analysis, patient-generated subjective global assessment, albumin, and the Functional Oral Intake Scale (FOIS) were evaluated before chemoradiotherapy and 6-8 weeks after its completion.Among the participants, cardiopulmonary fitness, hand grip strength, and phase angle of BC-BIA declined during chemoradiotherapy. Before and after chemoradiotherapy, V̇O2peak was 19.6 ± 4.4 and 17.4 ± 3.9 mL/min/kg respectively. The improvement in FOIS during chemoradiotherapy showed a positive correlation with changes in aerobic capacity. Additionally, exercise training was associated with attenuating the decline in aerobic capacity.Physical fitness deteriorated in patients with oesophageal cancer following chemoradiotherapy. Improvement in dysphagia helps maintain aerobic capacity. Additionally, exercise training has the potential to mitigate the decline. This discovery can serve as a reference for enhancing holistic care for patients with oesophageal cancer.