食管癌患者的化学放射治疗后，改善功能性口服摄入和运动训练减轻了有氧运动能力下降
Improved functional oral intake and exercise training attenuate decline in aerobic capacity following chemoradiotherapy in patients with esophageal cancer
影响因子:2.30000
分区:医学4区 / 康复医学3区 运动科学4区
发表日期:2024 Oct 18
作者:
Shu-Chun Huang, Lan-Yan Yang, Yin-Kai Chao, Wei-Yang Chang, Ya-Tzu Tsao, Chuan-Yi Chou, Ching-Chung Hsiao, Chien-Hung Chiu
摘要
为了研究化学放疗对食管癌患者身体适应性的影响，以及影响它的临床因素。总共有67名参与者成功地完成了这项研究，其中18个参与者从事监督的内科有氧运动训练，以中等强度进行20个会话。心肺运动测试，手抓地力，通过生物选择性阻抗分析评估，患者生成的主观全球评估，白蛋白和功能性口服摄入量表（FOIS）在化学诊所之前进行评估，并在完成后6-8周进行了6-8周的时间。化学放射治疗之前和之后，Vïo2peak分别为19.6±4.4和17.4±3.9 ml/min/kg。化学放疗期间的球的改善表现出与有氧能力变化的正相关。此外，运动训练与减轻有氧运动能力的下降有关。化学放疗后食道癌患者的身体健康状况恶化。吞咽困难的改善有助于维持有氧能力。此外，运动训练有可能减轻下降。该发现可以作为增强食道癌患者整体护理的参考。
Abstract
To investigate the impact of chemoradiotherapy on the physical fitness of patients with oesophageal cancer, and the clinical factors influencing it.A total of 67 participants successfully completed the study, with 18 of them engaging in supervised, in-hospital aerobic training at moderate intensity for a minimum of 20 sessions. Cardiopulmonary exercise testing, hand grip strength, body composition assessed via bioelectrical impedance analysis, patient-generated subjective global assessment, albumin, and the Functional Oral Intake Scale (FOIS) were evaluated before chemoradiotherapy and 6-8 weeks after its completion.Among the participants, cardiopulmonary fitness, hand grip strength, and phase angle of BC-BIA declined during chemoradiotherapy. Before and after chemoradiotherapy, V̇O2peak was 19.6 ± 4.4 and 17.4 ± 3.9 mL/min/kg respectively. The improvement in FOIS during chemoradiotherapy showed a positive correlation with changes in aerobic capacity. Additionally, exercise training was associated with attenuating the decline in aerobic capacity.Physical fitness deteriorated in patients with oesophageal cancer following chemoradiotherapy. Improvement in dysphagia helps maintain aerobic capacity. Additionally, exercise training has the potential to mitigate the decline. This discovery can serve as a reference for enhancing holistic care for patients with oesophageal cancer.