宫颈癌是埃塞俄比亚女性第二常见的癌症。然而，有关人乳头瘤病毒 (HPV) 基因型流行率的数据有限。从埃塞俄比亚各地 7 个医疗机构就诊的 783 名妇女连续获得自我阴道灌洗样本。通过多重乳头瘤病毒基因分型评估基因型流行率，该方法可检测并单独识别 51 种基因型和 3 种亚型。描述了基因型特异性患病率，并分析了与已知危险因素的关联。 HPV 总体患病率（18-45 岁）为 33.1%（95% 置信区间 (CI) 29.8-36.4）。农村和城市人口的 HPV 患病率不同，分别为 17.6% (95% CI 11.6-23.7) 和 36.8% (95% CI 33.1-40.6)（p < 0.001 卡方检验）。最常见的高危类型是 HPV 16（6.6%），其次是 HPV 52（4.3%）、51 和 39（均为 2.9%）。与农村女性相比，城市女性 HPV 阳性的风险更高（比值比 2.36（95% CI 1.47-3.79；p < 0.001）。首次性行为年龄≤15 岁和一夫多妻制丈夫（城市女性）也增加了风险HPV 阳性率接近两倍，埃塞俄比亚育龄妇女的 hr-HPV 患病率较高，这表明非有效 HPV 疫苗涵盖了本研究中发现的最常见的 hr-HPV 基因型。因此，由于产前护理是利用得最好的卫生服务，因此实施自我取样阴道灌洗可能是对该年龄组进行筛查的一个机会，但仍需要确定筛查算法和分诊以避免对这些妇女进行过度治疗。 .© 作者；被许可人 ecancermedicalscience。

Cervical cancer is the second most commonly diagnosed cancer in women in Ethiopia. However, data are limited on the prevalence of human papillomavirus (HPV) genotypes. Self-sampled vaginal lavages were obtained consecutively from 783 women attending 7 health facilities across Ethiopia. Genotype prevalence was assessed by Multiplex-Papillomavirus-Genotyping which detects and individually identifies 51 genotypes and 3 subtypes. Genotype-specific prevalence was described and associations with known risk factors were analysed. The overall HPV prevalence (age range 18-45) was 33.1% (95% confidence interval (CI) 29.8-36.4). The prevalence of HPV was different in the rural and urban population with 17.6% (95%CI 11.6-23.7) and 36.8% (95%CI 33.1-40.6) (p < 0.001 chi-square test), respectively. The most common high-risk types were HPV 16 (6.6%), followed by HPV 52 (4.3%), 51 and 39 (both 2.9%). Urban women compared to rural women had a higher risk of being HPV positive (odds ratio 2.36 (95% CI 1.47-3.79; p < 0.001). Age at sexual debut ≤15 years and polygamous husband (in urban women) also increased the risk of being HPV positive nearly two-fold. The high prevalence of hr-HPV in Ethiopian women in the reproductive age group shows the need for screening programs. The nonavalent HPV vaccine covers the most prevalent hr-HPV genotypes as found in this study and can therefore be used effectively. Since antenatal care is the best-utilised health service, implementing self-sampled vaginal lavage could be an opportunity for screening in this age group. Screening algorithms and triage still need to be defined to avoid over-treatment in these women.© the authors; licensee ecancermedicalscience.