线粒体在肝细胞癌维持癌症干细胞中的作用
Mitochondria's Role in the Maintenance of Cancer Stem Cells in Hepatocellular Carcinoma
影响因子:4.20000
分区:医学3区 / 细胞与组织工程3区 细胞生物学3区 医学：研究与实验3区
发表日期:2025 Jan
作者:
Manar A Elhinnawi, Michael Ibrahim Boushra, Donia Mohamed Hussien, Fatema Hesham Hussein, Islam Ahmed Abdelmawgood
摘要
肝细胞癌（HCC）是肝癌的主要形式，被认为是全球与癌症相关死亡率的主要因素。癌症干细胞（CSC）是一组很小的癌细胞，具有重生，形成肿瘤并经历分化的重要能力。 CSC在开始，传播，复发和对癌症治疗的抗性中具有关键作用。结果，它们非常容易受到治疗干预的目标。可以通过有效靶向消除癌症干细胞的药物来治愈HCC的潜力。线粒体通过线粒体代谢，生物发生和动力学来赋予对癌细胞的耐药性具有至关重要的功能。线粒体代谢过程的功能障碍，例如线粒体氧化磷酸化（OXPHOS），钙信号传导和活性氧（ROS）产生，有助于包括HCC在内的人类恶性肿瘤的起始和进展。 ROS取决于其浓度，既有益和有害影响。因此，在研究HCC的基本机制的研究中，ROS已成为一个突出的主题。此外，在创建新线粒体的过程中的失衡是CSC的一个特征，线粒体生物发生的增加与CSC中观察到的耐药性的增强有关。本文详细介绍了线粒体参与CSC和HCC的传播。对线粒体如何参与肿瘤发生和耐药性的更深入了解可能会导致发现新型的癌症治疗方法。
Abstract
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is recognized as a major contributor to cancer-related mortality worldwide. Cancer stem cells (CSCs) are a tiny group of cancer cells that possess a significant ability to regenerate themselves, form tumors, and undergo differentiation. CSCs have a pivotal role in the initiation, spread, recurrence, and resistance to treatment of cancer. As a result, they are very susceptible to being targeted for therapeutic intervention. The potential to cure HCC may be achieved by efficiently targeting drugs that eradicate cancer stem cells. Mitochondria have a crucial function in granting drug resistance to cancer stem cells by means of mitochondrial metabolism, biogenesis, and dynamics. Dysfunction in mitochondrial metabolic processes, such as mitochondrial oxidative phosphorylation (OXPHOS), calcium signaling, and reactive oxygen species (ROS) generation, contributes to the initiation and progression of human malignancies, including HCC. ROS have both beneficial and detrimental effects depending on their concentration. Consequently, ROS have become a prominent subject in the study of the fundamental mechanisms of HCC. Furthermore, an imbalance in the process of creating new mitochondria is a characteristic feature of CSCs, and an increase in mitochondrial biogenesis is associated with the heightened resistance observed in CSCs. This article provides a detailed examination of the involvement of mitochondria in the preservation of CSCs, as well as the spread of HCC. A deeper understanding of how mitochondria participate in tumorigenesis and drug resistance could result in the discovery of novel cancer treatments.