描述新诊断的妇科癌症手术前至术后 2 年的下肢症状；探讨下肢症状、下肢淋巴水肿、身体形象、生活质量、焦虑和抑郁之间的关系；并确定下肢症状是否预示下肢淋巴水肿。前瞻性收集了 408 名妇科癌症女性术前和术后 6 个月的 14 种下肢症状、淋巴水肿、身体形象、焦虑、抑郁和生活质量。术后 12 个月和 24 个月。计算症状的点患病率和累积发生率。探讨了所有时间点症状、下肢淋巴水肿和健康相关结果之间的横断面关系，同时使用回归分析来评估术后 6 个月下肢症状与术后 12 个月淋巴水肿之间的预测关系。以及术后 24 个月。参与者平均年龄 59 (SD: 11) 岁，分别有 58%、28%、9% 和 5% 被诊断患有子宫内膜癌、卵巢癌、宫颈癌和外阴/阴道癌。所有癌症类型中任何特定下肢症状的患病率在 11% 至 59% 之间，最常见的症状是疼痛、僵硬和酸痛（所有时间点的患病率 >40%）。症状的存在与较高的焦虑和抑郁、较差的整体生活质量和身体形象相关（p < 0.01）。与没有症状的患者相比，至少轻度严重的一种或多种下肢症状会增加术后 24 个月内发生淋巴水肿的几率 (OR > 1.3)。自我报告的症状与不良健康相关结果相关。无论症状严重程度如何，对症状进行评估和管理都有可能改善妇科癌症患者的健康结果，包括淋巴水肿。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

To describe lower-limb symptoms pre- through to 2-years post-surgery following newly diagnosed gynecological cancer; to explore relationships between lower-limb symptoms, lower-limb lymphedema, body image, quality of life, anxiety and depression; and to determine whether lower-limb symptoms predict lower-limb lymphedema.Fourteen lower-limb symptoms, lymphedema, body image, anxiety, depression, and quality of life were prospectively collected in 408 women with gynecological cancer pre-surgery, and at 6-, 12-, and 24-months post-surgery. Point prevalence and cumulative incidence were calculated for symptoms. Cross-sectional relationships were explored between symptoms, lower-limb lymphedema and health-related outcomes at all timepoints, while regression analyses were used to assess the predictive relationships between lower-limb symptoms at 6-months post-surgery, and lymphedema at 12- and 24-months post-surgery.Participants were on average 59 (SD: 11) years of age, and 58 %, 28 %, 9 % and 5 % were diagnosed with endometrial, ovarian, cervical, and vulvar/vaginal cancer, respectively. Prevalence of any given lower limb symptom among all cancer types ranged between 11 and 59 %, with the most prevalent symptoms being pain, stiffness, and aching (prevalence >40 % across all time-points). The presence of symptoms was associated with higher anxiety and depression, poorer overall quality of life and body image (p < 0.01). Compared to those without symptoms, one or more lower limb symptoms of at least mild severity increased the odds of developing lymphedema up to 24 months post-surgery (OR > 1.3).Self-reported symptoms are associated with adverse health-related outcomes. Assessment and management of symptoms, irrespective of symptom severity, has potential for improving health outcomes, including lymphedema, in those following gynecological cancer.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.