硫化氢：对癌细胞生存来说有点麻烦。
Hydrogen sulfide: A whiff of trouble for cancer cell survival.
发表日期：2024 Oct 17
作者：
Jung Seung Nam, Maya S Dixon, Iok In Christine Chio
来源：
MOLECULAR CELL
摘要：
硫化氢 (H2S) 可以通过在选定的半胱氨酸残基上对蛋白质进行翻译后过硫化来调节生物过程。在本期《分子细胞》中，Zheng 等人1 将酶 SAHH 鉴定为 H2S 底物，过硫化后会破坏同型半胱氨酸代谢并使肺癌细胞对铁死亡敏感。版权所有 © 2024 Elsevier Inc. 保留所有权利。
Hydrogen sulfide (H2S) can regulate biological processes by post-translational persulfidation of proteins at select cysteine residues. In this issue of Molecular Cell, Zheng et al.1 identify the enzyme SAHH as an H2S substrate, which upon persulfidation disrupts homocysteine metabolism and sensitizes lung cancer cells to ferroptosis.Copyright © 2024 Elsevier Inc. All rights reserved.