宫颈腺癌 (AUC) 的预后比鳞状细胞癌差。碳离子放射治疗 (CIRT) 的 AUC 结果已在回顾性或单一机构前瞻性研究中报告，但未在前瞻性多中心研究中报告。我们在一项前瞻性多中心研究中展示了针对 AUC 的 CIRT 结果，该研究利用日本全国范围内的医院登记系统。本研究纳入了 2016 年 6 月至 2020 年 4 月期间在 4 个日本中心接受 CIRT 的局部晚期未经治疗的 AUC 患者。在没有器官功能障碍的情况下，每周进行最多 5 个 40 mg/m2 顺铂疗程。主要终点是 2 年总生存率 (OS) 和局部控制率 (LC)。次要终点是 2 年无病生存 (DFS) 率和晚期不良事件 (AE)。 42 名患者入组，中位年龄为 54 岁（范围为 34-76 岁）。患者被诊断患有 IIB 期 (n=26)、IIIB (n=12) 或 IVA (n=4) 期疾病。中位随访期为 24 个月。 2 年 OS、LC 和 DFS 率为 97.5%（95% 置信区间 [CI] 92.7-100.0%）、80.9%（95% CI 66.9-94.8%）和 64.3%（48.1-80.4%），分别。两名患者出现 3 级直肠/乙状结肠 AE。一名患者因局部肿瘤复发（3 级泌尿生殖 AE）而在抢救手术中需要进行尿流改道手术。没有其他 3 级或更严重毒性的报告。CIRT 是局部晚期 AUC 的有效治疗方法。需要进一步研究来验证 AUC 的 CIRT 的安全性和有效性。版权所有 © 2024。由 Elsevier Inc. 出版。

Prognoses are poorer in cases of adenocarcinoma of the uterine cervix (AUC) than of squamous cell carcinoma. Carbon-ion radiotherapy (CIRT) outcomes for AUC have been reported in retrospective or single institutional prospective studies but not prospective multicenter studies. We present the results of CIRT for AUC in a prospective multicenter study utilizing a nationwide hospital-based registry in Japan.Patients with locally advanced untreated AUC who received CIRT at 4 Japanese centers between June 2016 and April 2020 were included in this study. In the absence of organ dysfunction, up to 5 weekly 40 mg/m2 cisplatin courses were administered. The primary endpoints were 2-year overall survival (OS) and local control (LC) rates. The secondary endpoints were 2-year disease-free survival (DFS) rate and late adverse events (AEs).Forty-two patients were enrolled with a median age of 54 years (range, 34-76 years). Patients were diagnosed with Stage IIB (n=26), IIIB (n=12), or IVA (n=4) disease. The median follow-up period was 24 months. The 2-year OS, LC, and DFS rates were 97.5% (95% confidence interval [CI] 92.7-100.0%), 80.9% (95% CI 66.9-94.8%), and 64.3% (48.1-80.4%), respectively. Two patients developed Grade 3 rectum/sigmoid AE. One patient required urinary diversion surgery during a salvage operation for local tumor recurrence (Grade 3 genitourinary AE). No other Grade 3 or worse toxicities were reported.CIRT is an effective treatment for locally advanced AUC. Further research is required to validate the safety and efficacy of CIRT for AUC.Copyright © 2024. Published by Elsevier Inc.