LncRNA 和癌症表观基因组：机制和治疗潜力。
LncRNAs and the Cancer Epigenome: Mechanisms and Therapeutic Potential.
发表日期：2024 Oct 16
作者：
Revathy Nadhan, Ciro Isidoro, Yong Sang Song, Danny N Dhanasekaran
来源：
CANCER LETTERS
摘要：
长非编码 RNA (lncRNA) 已成为表观基因组的关键调节因子，通过 DNA 甲基化、组蛋白修饰和/或染色体重塑来调节基因表达。失调的lncRNA充当癌基因或肿瘤抑制因子，通过塑造癌症表观基因组来驱动肿瘤进展。通过与表观遗传脚本的书写者、阅读者和擦除者相互作用，lncRNA诱导表观遗传修饰，从而导致癌细胞增殖、凋亡、上皮-间质转化、迁移、侵袭、转移、癌症干性和化疗耐药性的变化。这篇综述分析并讨论了 lncRNA 在癌症病理学中的多方面作用，从癌症的发生和进展到转移和治疗耐药。它还通过创新的诊断、预后和治疗策略探索了靶向 lncRNA 的治疗潜力。了解 lncRNA 和表观基因组之间的动态相互作用对于制定个性化治疗策略至关重要，为精准癌症医学提供新途径。版权所有 © 2024。由 Elsevier B.V. 出版。
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of epigenome, modulating gene expression through DNA methylation, histone modification, and/or chromosome remodeling. Dysregulated lncRNAs act as oncogenes or tumor suppressors, driving tumor progression by shaping the cancer epigenome. By interacting with the writers, readers, and erasers of the epigenetic script, lncRNAs induce epigenetic modifications that bring about changes in cancer cell proliferation, apoptosis, epithelial-mesenchymal transition, migration, invasion, metastasis, cancer stemness and chemoresistance. This review analyzes and discusses the multifaceted role of lncRNAs in cancer pathobiology, from cancer genesis and progression through metastasis and therapy resistance. It also explores the therapeutic potential of targeting lncRNAs through innovative diagnostic, prognostic, and therapeutic strategies. Understanding the dynamic interplay between lncRNAs and epigenome is crucial for developing personalized therapeutic strategies, offering new avenues for precision cancer medicine.Copyright © 2024. Published by Elsevier B.V.