口腔人乳头瘤病毒 (HPV) 与口咽癌 (OPC) 相关。尽管 OPC 发病率在全球范围内不断增加，但对口腔 HPV 感染率的了解仍然有限。在此，我们对 2005 年至 2009 年间来自美国、墨西哥和巴西的 3,137 名男性的口腔 HPV 发病率进行了观察性流行病学分析。对个体的新 HPV 感染进行了中位随访 57 个月。还评估了累积发生率和与获得相关的因素。口腔致癌性 HPV 的发病率为每 1000 人月 2.4 例，不随年龄变化，并且在整个研究期间保持恒定。口腔 HPV 感染的风险与饮酒、拥有男性性伴侣、更多终生女性性伴侣、更多的口交和更高的教育程度显着相关。这些数据表明，男性一生中都有感染口腔 HPV 的风险，这表明补种疫苗可能会减少新感染的发生率。© 2024。作者，获得 Springer Nature Limited 的独家许可。

Oral human papillomavirus (HPV) is associated with oropharyngeal cancer (OPC). Although OPC incidence is increasing globally, knowledge of oral HPV infection rates is limited. Here we carried out an observational epidemiological analysis of oral HPV incidence in 3,137 men enrolled from the United States, Mexico and Brazil between 2005 and 2009. Individuals were followed for new HPV infection for a median of 57 months. Cumulative incidence and factors associated with acquisition were also assessed. The incidence rate of oral oncogenic HPV was 2.4 per 1,000 person-months, did not vary with age and was constant throughout the study period. Risk of oral HPV acquisition was significantly associated with alcohol consumption, having male sexual partners, more lifetime female sexual partners, more oral sex given and higher educational attainment. These data indicate that men are at risk of acquiring oral HPV throughout their lifetime, suggesting that catch-up vaccination may reduce new infection incidence.© 2024. The Author(s), under exclusive licence to Springer Nature Limited.