淋巴图谱是一种绘制口腔癌引流模式的成熟技术。其在既往接受过放疗或颈清扫术的患者中的效用尚未得到充分研究。考虑在 2021 年至 2023 年间因复发/第二次口腔癌而到单一三级癌症中心就诊并接受淋巴图谱检查的患者。所有患者都有接受放射或颈清扫术治疗的头颈癌病史。我们进一步在 MEDLINE、Embase 和 Web of Science 上对既往接受过颈部治疗的口腔癌患者的淋巴图谱进行了范围审查。在我们的单中心审查中，总共纳入了 11 名患者。 73% 的人之前接受过放射治疗，55% 的人之前因头颈癌接受过颈部清扫术。淋巴闪烁扫描引导的颈部清扫术在 9/11 的患者中发现了前哨淋巴结，只有一名患者的前哨淋巴结疾病呈阳性。中位 10 个月的随访中没有区域复发的报告。我们对 980 项研究进行了范围审查，确定了另外 151 名患者，他们在之前的颈部治疗后因第二次口腔癌接受了前哨淋巴结活检。总体而言，所有研究中淋巴图谱的阴性预测值为 96.7%。即使对于既往接受过颈部放疗或手术治疗的患者，淋巴图谱对于继发性或复发性口腔癌也是可行的。迄今为止的文献表明前哨淋巴结定位的阴性预测值约为 97%，值得在挽救性口腔癌的治疗中进一步考虑。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Lymphatic mapping is an established technique to map drainage patterns in oral cancer. Its utility in patients who have undergone prior radiation or neck dissection is not well studied.Patients presenting to a single tertiary cancer center between 2021-2023 for a recurrent/second oral cancer that underwent lymphatic mapping were considered. All patients had a history of a head and neck cancer treated with either radiation or neck dissection. We further conducted a scoping review in MEDLINE, Embase, and Web of Science of lymphatic mapping in oral cancer patients with previous neck treatment.In our single center review, a total of 11 patients were included. 73 % received prior radiotherapy and 55 % underwent prior neck dissections for a head and neck cancer. Lymphoscintigraphy-directed neck dissections identified sentinel nodes in 9/11 patients, with only one patient who had positive sentinel node disease. There were no reports of regional recurrence at a median of 10 months follow-up. Our scoping review of 980 studies identified 151 additional patients who underwent sentinel node biopsy for a second oral cancer after previous neck treatment. Overall, the negative predictive value of lymphatic mapping in all studies was 96.7 %.Lymphatic mapping is feasible in secondary or recurrent oral cavity cancers even in patients with prior radiation or surgical management of the neck. The literature to date demonstrates a negative predictive value of ∼ 97 % for sentinel node mapping and warrants further consideration in the management of salvage oral cancer.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.