癌症淋巴结转移：拨开云雾看到黎明。
Lymph node Metastasis in Cancer: Clearing the Clouds to See the Dawn.
发表日期：2024 Oct 17
作者：
Zi-Zhan Li, Kan Zhou, Qiuji Wu, Bing Liu, Lin-Lin Bu
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
摘要：
淋巴结转移（LNM）通常被认为是各种癌症预后不良的指标。尽管自发现以来已经进行了三个多世纪的探索，但 LNM 背后的分子机制仍然没有定论。本文综述了LNM的分子机制，并利用“PUMP”原理进行阐明。病理检查仍然是LNM诊断的金标准，但需要探索能够有效改善患者预后的早期诊断策略。随着免疫疗法的出现，出现了关于淋巴结 (LN) 命运的讨论，强调在免疫疗法之前保持 LN 完整性的重要性。这反过来又对LNM的诊断准确性和精准治疗提出了更高的要求。该综述全面讨论了癌症淋巴结转移的分子机制、诊断方法和治疗策略，以及该领域目前的瓶颈和未来方向。版权所有 © 2024 Elsevier B.V. 保留所有权利。
Lymph node metastasis (LNM) is often regarded as an indicator of poor prognosis in various cancers. Despite over three centuries of exploration since its discovery, the molecular mechanisms underlying LNM remain inconclusive. This review summarizes the molecular mechanisms of LNM, using the "PUMP+" principle for clarification. Pathological examination remains the gold standard for LNM diagnosis, yet there is a need to explore early diagnostic strategies that can effectively improve patient outcomes. With the advent of immunotherapy, discussions on the fate of lymph nodes (LN) have emerged, emphasizing the importance of preserving LN integrity prior to immunotherapy. This, in turn, poses higher demands for diagnostic accuracy and precision treatment of LNM. This review comprehensively discusses the molecular mechanisms, diagnostic methods, and treatment strategies for cancer lymph node metastasis, along with current bottlenecks and future directions in this field.Copyright © 2024 Elsevier B.V. All rights reserved.