癌症免疫治疗中产生 IL-9 的 T 细胞的功能多样性和调节。
Functional diversity and regulation of IL-9-producing T cells in cancer immunotherapy.
发表日期：2024 Oct 17
作者：
Muhammad Kalim, Rui Jing, Wei Guo, Hui Xing, Yong Lu
来源：
CANCER LETTERS
摘要：
产生 IL-9 的 T 细胞 (T9) 调节影响各种细胞生物学过程的免疫反应，但其精确功能仍被完全了解。先前的研究已将 T9 细胞与过敏性疾病、寄生虫感染清除和各种癌症等疾病联系起来。虽然 IL-9 和 T9 细胞在癌症发展中的功能异质性已得到证实，但这些细胞为治疗实体瘤提供了有希望的治疗机会。本综述强调了 IL-9 和 T9 细胞在癌症进展和治疗反应中的作用，重点关注小鼠肿瘤和癌症患者之间 IL-9/IL-9R 信号传导的潜在差异。此外，我们还讨论了肿瘤特异性 Th9/Tc9 细胞分化的调节、这些细胞的治疗潜力以及当前增强其抗肿瘤活性的策略。版权所有 © 2024。由 Elsevier B.V. 出版。
IL-9-producing T cells (T9) regulate immunological responses that affect various cellular biological processes, though their precise function remains fully understood. Previous studies have linked T9 cells to conditions such as allergic disorders, parasitic infection clearance, and various types of cancers. While the functional heterogeneity of IL-9 and T9 cells in cancer development has been documented, these cells present promising therapeutic opportunities for treating solid tumors. This review highlights the roles of IL-9 and T9 cells in cancer progression and treatment responses, focusing on potential discrepancies in IL-9/IL-9R signaling between murine tumors and cancer patients. Additionally, we discuss the regulation of tumor-specific Th9/Tc9 cell differentiation, the therapeutic potential of these cells, and current strategies to enhance their anti-tumor activities.Copyright © 2024. Published by Elsevier B.V.