旨在探讨美国高脂血症成人牙周炎与全因死亡率和特定原因死亡率之间的关系。参与者是从 1988-1994 年、1999-2004 年和 2009-2014 年期间的 NHANES 中提取的。为了评估中度至重度牙周炎与全因死亡率和特异死亡率之间的关联，使用以下方法计算风险比 (HR)、时间比 (TR) 及其各自的 95% 置信区间 (CI) Cox 比例风险和 Weibull 加速失效时间 (AFT) 模型。在中位随访时间 11.83 年中，记录了 16,848 名参与者中有 4,623 人死亡。多变量 Cox 回归和 AFT 分析显示，中重度牙周炎与全因风险增加相关（HR：1.31，95% CI：1.20-1.44，P < 0.001；TR：0.85，95% CI：0.80- 0.90，P < 0.001），心血管疾病（CVD）相关（HR：1.36，95％CI：1.14-1.63，P = 0.001；TR：0.83，95％CI：0.75-0.92，P < 0.001）和癌症-相关死亡率（HR：1.35，95% CI：1.12-1.63，P = 0.002；TR：0.82，95% CI：0.72-0.93，P = 0.002）。与此同时，随着牙周炎严重程度的增加，死亡风险呈显着上升趋势（趋势P < 0.001）。我们的研究强调，中度至重度牙周炎与全因CVD相关风险增加相关以及美国高脂血症成人的癌症相关死亡率。死亡风险随着牙周炎的严重程度而增加。© 2024。作者。

To explore the association between periodontitis and all-cause as well as cause-specific mortality rates in U.S. adults with hyperlipidemia.Participants were extracted from NHANES during 1988-1994, 1999-2004 and 2009-2014 periods. To assess the association between moderate-to-severe periodontitis and mortality rates for both all-cause and cause-specific mortality, hazard ratios (HRs), time ratios (TRs), and their respective 95% confidence intervals (CIs) were calculated using Cox proportional hazards and Weibull accelerated failure time (AFT) models.Over a median follow-up duration of 11.83 years, 4,623 deaths of 16,848 participants were recorded. Multivariate Cox regression and AFT analyses showed moderate-to-severe periodontitis were associated with an increased risk of all-cause (HR: 1.31, 95% CI: 1.20-1.44, P < 0.001; TR: 0.85, 95% CI: 0.80-0.90, P < 0.001), cardiovascular disease (CVD)-related (HR: 1.36, 95% CI: 1.14-1.63, P = 0.001; TR: 0.83, 95% CI: 0.75-0.92, P < 0.001) and cancer-related mortality ( HR: 1.35, 95% CI: 1.12-1.63, P = 0.002; TR: 0.82, 95% CI: 0.72-0.93, P = 0.002). Meanwhile, there was a significant upward trend in the risk of mortality with increasing severity of periodontitis (P for trend < 0.001).Our study highlights the moderate-to-severe periodontitis is associated with an increased risk of all-cause, CVD-related and cancer-related mortality among U.S. adults with hyperlipidemia. And the mortality risk increasing alongside the severity of periodontitis.© 2024. The Author(s).