四环素再探：四环素在皮肤科领域的应用
Tetracyclines Revisited: Tetracyclines in the Field of Dermatology
DOI 原文链接
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影响因子:2.7
分区:医学3区 / 皮肤病学3区
发表日期:2024
作者:
Yoon-Seob Kim, Hei Sung Kim
DOI:
10.1159/000542006
摘要
四环素是一类广谱抗生素，深受皮肤科医生的青睐。在过去十年中，四环素在多种皮肤疾病的临床疗效得到拓展。本综述旨在总结四环素在皮肤科的潜在适应症及其作用机制。本文涵盖除痤疮和酒渣鼻外的所有可能适应症，包括化脓性汗腺炎、自身免疫性水疱性皮肤病、白癜风、脱发、色素性瘙痒症、肉芽肿性皮肤病、卡波氏肉瘤、冷荨麻疹、特应性皮炎、刮擦性斑疹、瘢痕形成及其他皮肤病。我们还关注最近获批的第三代窄谱四环素——Sarecycline的临床疗效及其对微生物群的潜在影响。本文旨在深化对这一常用药物类别的理解，鼓励其在更广泛的皮肤疾病和症状中的应用。本研究全面回顾了四环素在皮肤科潜在适应症的最新文献。
Abstract
Tetracyclines are a class of broad-spectrum antibiotics favored by dermatologists. Over the last decade, the clinical efficacy of tetracyclines has expanded into various dermatoses.This review tries to encompass the possible indications of tetracycline in the field of dermatology and possible mechanisms of action. This comprehensive review encompasses all possible indications of tetracyclines besides acne vulgaris and rosacea: hidradenitis suppurativa, autoimmune bullous dermatoses, vitiligo, alopecia, prurigo pigmentosa, granulomatous dermatoses, Kaposi's sarcoma, cold urticaria, atopic dermatitis, scrub typhus, scarring, and miscellaneous dermatoses. We also focus on the recently approved sarecycline, a third-generation narrow-spectrum tetracycline, and its clinical efficacy and potential impact on the microbiome. Our review provides a better understanding of this extremely familiar drug class and encourages its use in a wider spectrum of dermatologic diseases and symptoms.This study comprehensively reviewed the current literature on potential indications of tetracyclines in the field of dermatology.