四环素是皮肤科医生青睐的一类广谱抗生素。在过去的十年中，四环素的临床疗效已扩展到各种皮肤病。本综述试图涵盖四环素在皮肤病学领域的可能适应症和可能的作用机制。这篇全面的综述涵盖了除寻常痤疮和红斑痤疮外四环素的所有可能适应症：化脓性汗腺炎、自身免疫性大疱性皮肤病、白癜风、脱发、色素性痒疹、肉芽肿性皮肤病、卡波西肉瘤、寒冷性荨麻疹、特应性皮炎、恙虫病、疤痕和杂种皮肤病。我们还关注最近批准的第三代窄谱四环素沙雷环素及其临床疗效和对微生物组的潜在影响。我们的评论使人们更好地了解这种极其熟悉的药物类别，并鼓励其在更广泛的皮肤病和症状中使用。作者。由巴塞尔 S. Karger AG 出版。

Tetracyclines are a class of broad-spectrum antibiotics favored by dermatologists. Over the last decade, the clinical efficacy of tetracyclines has expanded into various dermatoses. This review tries to encompass the possible indications of tetracycline in the field of dermatology and possible mechanisms of action. This comprehensive review encompasses all possible indications of tetracyclines besides acne vulgaris and rosacea: hidradenitis suppurativa, autoimmune bullous dermatoses, vitiligo, alopecia, prurigo pigmentosa, granulomatous dermatoses, Kaposi sarcoma, cold urticaria, atopic dermatitis, scrub typhus, scarring, and miscellaneous dermatoses. We also focus on the recently approved sarecycline, a third generation narrow-spectrum tetracycline, and its clinical efficacy and potential impact on the microbiome. Our review provides a better understanding of this extremely familiar drug class and encourages its use in a wider spectrum of dermatologic diseases and symptoms.The Author(s). Published by S. Karger AG, Basel.