癌症缺氧的起源和分子效应。
Origins and molecular effects of hypoxia in cancer.
发表日期：2024 Oct 18
作者：
Sergio Rey-Keim, Luana Schito
来源：
SEMINARS IN CANCER BIOLOGY
摘要：
缺氧（氧气不足）是癌症进展的关键因素，会引发与治疗抵抗、转移和患者死亡率相关的遗传、转录、翻译和表观遗传适应。在这篇综述中，我们概述了导致原位和体外缺氧癌细胞适应的微环境起源和分子机制，同时概述了在精准肿瘤学背景下分层、量化和治疗目标缺氧的当前方法。版权所有 © 2024。由爱思唯尔出版有限公司
Hypoxia (insufficient O2) is a pivotal factor in cancer progression, triggering genetic, transcriptional, translational and epigenetic adaptations associated to therapy resistance, metastasis and patient mortality. In this review, we outline the microenvironmental origins and molecular mechanisms responsible for hypoxic cancer cell adaptations in situ and in vitro, whilst outlining current approaches to stratify, quantify and therapeutically target hypoxia in the context of precision oncology.Copyright © 2024. Published by Elsevier Ltd.