评估急性淋巴细胞白血病的新发育儿童的大脑结构变化
Assessing changes in brain structure in new-onset children with acute lymphoblastic leukemia
影响因子:3.10000
分区:医学3区 / 儿科2区
发表日期:2025 Jun
作者:
Shu Su, Hua-Qiong Qiu, Lian-Hong Cai, Wei-Feng Hou, Shu-Zhen Huang, Li-Bin Huang, Long Qian, Wei Cui, Yian-Qian Chen, Zhi-Yun Yang, Yan-Lai Tang, Li-Ping Lin
摘要
治疗后，脑结构损伤在急性淋巴细胞白血病（全部）中呈现；但是，其在新阶段的变化仍不清楚。我们旨在使用基于表面的形态计算（SBM）和基于区域的空间统计（TBS）探索白质（WM）和灰质（GM）的变化，全部均可招募33个儿童（TD）儿童，并进行了前进和经过三维的T1-Weefuse和Diftie（TD）的33名儿童（TD）。在组差异之间比较了DTI指标，皮层GM特征和深GM核的体积。在所有组之间，callosum callosum体内唯一增加的FA（PFWE训练= 0.023），并提出了左上的Corona Radiata（Pfwe = 0.045）。相对于TDS，小儿均显示出轨道表面积（CSA），厚度（CT）和体积的显着降低，轨道回旋，超肌后回，中间颞回和上级颞回（所有CWP = 0.01）。另外，在舌回和左沟中发现了CT和CSA增加（所有CWP = 0.01）。小儿的体积较小，在双侧丘脑，尾矿，海马和右核核酸菌（PFDR校正<0.05 <0.05）中都观察到所有的脑结构异常。白血病在新舞台上。建议在化学疗法之前可能存在结构性损害。 MRI是对儿童急性淋巴细胞白血病的脑结构损伤的早期检测的一种敏感方法。
Abstract
Brain structure injury was presented in acute lymphoblastic leukemia (ALL) after treatment; however, its alterations in new-onset stage are still unclear. We aim to explore white matter (WM) and grey matter (GM) alterations using surface-based morphometry (SBM) and tract-based spatial statistics (TBSS) in new-onset pediatric ALL.Thirty-five ALL and 33 typically developing (TD) children were prospectively recruited and underwent three-dimensional T1-weighted and diffusion tensor (DTI) imaging. DTI metrics, cortical GM features, and deep GM nuclei volume were compared between groups differences.In ALL, the only increased FA in the body of corpus callosum (PFWE-corrected = 0.023) and left superior corona radiata (PFWE-corrected = 0.045) were presented. Relative to TDs, pediatric ALL presented a significant decrease in cortical surface area (CSA), thickness (CT), and volume in orbital gyri, supramarginal gyrus, middle temporal gyrus, and superior temporal gyrus (all CWP = 0.01). Additionally, increased CT and CSA were found in lingual gyrus and left sulcus intermedius primus, respectively (all CWP = 0.01). Smaller volumes in pediatric ALL were observed in bilateral thalamus, caudate, hippocampus, and right putamen (PFDR-corrected < 0.05).Widespread brain structural abnormalities were found in new-onset pediatric ALL, which suggest disease itself can cause brain structural injury.This study revealed the altered white matter integrity and gray matter morphology characteristics in childhood acute lymphoblastic leukemia on new-onset stage. It is suggested that there may be structural impairment before chemotherapy. MRI is a sensitive way for early detection on brain structural damage in childhood acute lymphoblastic leukemia.