格里森评分是前列腺癌 (PCa) 分级的黄金标准，通过为不同的微观生长模式分配特定等级来进行评估。除了格里森分级之外，最近显示诸如筛状结构等个体生长模式对疾病结果具有独立的预后价值。 PCa 分级是对某一时间点收集的静态组织样本进行的，而体内上皮肿瘤结构是动态侵入、分支和扩展到周围基质的。由于缺乏能够随着时间的推移跟踪人类 PCa 微观发展的模型，我们对潜在组织动力学的了解很少。我们假设人类 PCa 扩增利用胚胎和发育性肾小管发生途径。本研究的目的是全面概述正常上皮小管形成、伸长和分支的发育途径，并将其与日常临床实践中观察到的静态显微 PCa 生长模式联系起来。这项研究可以为观察者之间的病理学变异性和 PCa 生长模式之间的临床结果差异提供理论依据。© 2024 作者。组织病理学由约翰·威利出版

The Gleason score is the gold standard for grading of prostate cancer (PCa) and is assessed by assigning specific grades to different microscopical growth patterns. Aside from the Gleason grades, individual growth patterns such as cribriform architecture were recently shown to have independent prognostic value for disease outcome. PCa grading is performed on static tissue samples collected at one point in time, whereas in vivo epithelial tumour structures are dynamically invading, branching and expanding into the surrounding stroma. Due to the lack of models that are able to track human PCa microscopical developments over time, our understanding of underlying tissue dynamics is sparse. We postulate that human PCa expansion utilizes embryonic and developmental tubulogenetic pathways. The aim of this study is to provide a comprehensive overview of developmental pathways of normal epithelial tubule formation, elongation, and branching, and relate those to the static microscopical PCa growth patterns observed in daily clinical practise. This study could provide a rationale for the discerned pathological interobserver variability and the clinical outcome differences between PCa growth patterns.© 2024 The Author(s). Histopathology published by John Wiley & Sons Ltd.