随着化疗相关认知障碍患病率的上升，对治疗方案的研究至关重要。本研究的目的是测试化疗期间开始的有氧运动干预与常规护理（候补名单控制条件）相比对（1）客观测量的认知功能和自我报告的认知功能以及（2）的影响。认知障碍对干预后生活质量 (QOL) 的影响（与化疗完成相当）。乳腺癌女性的有氧运动和认知功能 (ACTIVATE) 试验是一项在渥太华进行的双组、双中心随机对照试验和温哥华（加拿大）。 57 名被诊断患有 I-III 期乳腺癌并正在等待化疗的女性（Mage，48.8 ± 10 岁）被随机分配到化疗开始时进行有氧运动 (nEX = 28) 或化疗期间进行常规护理，化疗完成后进行有氧运动 (nUC = 29）。干预持续 12-24 周，包括监督有氧训练和家庭锻炼。主要结果是通过 13 项神经心理学测试测量的客观认知功能（标准化为 M ± SD，0 ± 1）；通过问卷评估自我报告的认知功能的次要结果及其对生活质量的影响。对干预前和干预后（主要终点）收集的数据进行了分析。尽管在考虑多重测试后，干预后的客观认知功能结果在各组之间没有发现显着差异，但六项自我报告的认知功能结果中有四项显示出有利于有氧运动的显着差异。运动组。在开始乳腺癌化疗的女性中，有氧运动并没有导致化疗完成后干预后客观认知功能的显着差异；然而，结果确实支持使用这种干预措施来改善自我报告的认知功能及其对生活质量的影响。© 2024 作者。 《癌症》由 Wiley periodicals LLC 代表美国癌症协会出版。

As the prevalence of chemotherapy-related cognitive impairment rises, investigation into treatment options is critical. The objectives of this study were to test the effects of an aerobic exercise intervention initiated during chemotherapy compared to usual care (wait list control condition) on (1) objectively measured cognitive function and self-reported cognitive function, as well as on (2) the impact of cognitive impairment on quality of life (QOL) postintervention (commensurate with chemotherapy completion).The Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial was a two-arm, two-center randomized controlled trial conducted in Ottawa and Vancouver (Canada). Fifty-seven women (Mage, 48.8 ± 10 years) diagnosed with stage I-III breast cancer and awaiting chemotherapy were randomized to aerobic exercise initiated with chemotherapy (nEX = 28) or usual care during chemotherapy with aerobic exercise after chemotherapy completion (nUC = 29). The intervention lasted 12-24 weeks and consisted of supervised aerobic training and at-home exercise. The primary outcome was objective cognitive function measured via 13 neuropsychological tests (standardized to M ± SD, 0 ± 1); secondary outcomes of self-reported cognitive function and its impact on QOL were assessed via questionnaires. Data collected pre- and postintervention (the primary end point) were analyzed.Although no significant differences between groups were found for objective cognitive function outcomes postintervention after accounting for multiple testing, four of six self-reported cognitive function outcomes showed significant differences favoring the aerobic exercise group.Among women initiating chemotherapy for breast cancer, aerobic exercise did not result in significant differences in objective cognitive function postintervention after chemotherapy completion; however, the results do support the use of this intervention for improving self-reported cognitive function and its impact on QOL.© 2024 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.