免疫原性细胞死亡诱导剂和 PD-1 阻断作为直肠癌的新辅助治疗。
Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer.
发表日期：2024
作者：
Yan Wang, Liwei Zhao, Zhen Zhang, Peng Liu
来源：
OncoImmunology
摘要：
免疫肿瘤学癌症治疗正在转向新辅助治疗。对于胃肠道癌症，特别是局部晚期直肠癌患者，新辅助化学免疫治疗通常会引起完全缓解，从而避免手术干预。最近的临床试验表明，基于奥沙利铂的化疗和 PD-1/PD-L1 靶向免疫疗法的组合可以在手术前安全地进行，并具有治疗目的。© 2024 作者。经泰勒许可出版
Immuno-oncological cancer management is shifting to neoadjuvant treatments. In patients with gastrointestinal cancers, particularly locally advanced rectal cancer, neoadjuvant chemoimmunotherapy often induce complete responses, hence avoiding surgical intervention. Recent clinical trials indicate that combinations of oxaliplatin-based chemotherapy and PD-1/PD-L1-targeting immunotherapy can be safely administered before surgery with curative intent.© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.