长期以来，中性粒细胞一直被认为在急性炎症中占据主导地位，这一度导致人们低估了中性粒细胞在慢性恶性肿瘤中的作用。现在人们认识到，中性粒细胞也大量渗透到肿瘤微环境中，并在肿瘤内形成高度丰富的免疫群体，称为肿瘤相关中性粒细胞（TAN）。近年来，人们对研究 TAN 的显着异质性和可塑性产生了浓厚的兴趣，学者们越来越多地关注 TAN 的多方面功能，因此人们致力于阐明其作为治疗靶点的潜力。然而，将 TAN 靶向免疫疗法转化为临床实践还有很长的路要走。因此，利用文献计量分析的方法全面评价TAN的研究现状、焦点和演变趋势具有重要意义。2000年至2024年TAN研究相关出版物摘自Web of Science核心合集。通过Microsoft Excel、VOSviewer、CiteSpace、R-bibliometrix等工具进行文献计量分析和可视化。文献计量分析共收录了58个国家/地区1000个机构的5291名学者发表的788篇出版物及相关文章在324种期刊上发表。尽管中国的出版物数量和机构排名前十，但美国是出版物质量最多的领先国家，也是全球合作中心。 FRONTIERS IN IMMUNOLOGY 发表的论文最多，而 CANCER RESEARCH 是同被引用最高的期刊。以色列教授Fridlender, Zvi G.是TAN领域引用次数和H指数最高的创始人、先驱和培育者。我们的分析预示了未来的发展轨迹：TAN 异质性、中性粒细胞胞外陷阱、TAN 与免疫细胞之间的串扰以及免疫治疗可能会成为未来研究的重点。首先进行全面的文献计量和视觉分析，以绘制当前的景观和知识结构TAN，为进一步研究提供了新的视角。准确识别不同的 TAN 亚群以及精确靶向关键的促肿瘤/抗肿瘤亚群，具有发展为 TAN 靶向免疫疗法的巨大潜力。版权所有 © 2024 肖、冯、艾尼、赵、丁和高。

Neutrophils have long been consistently adjudged to hold a dominant position in acute inflammation, which once led people to undervalue their role in chronic malignancy. It is now acknowledged that neutrophils also infiltrate into the tumor microenvironment in substantial quantities and form a highly abundant immune population within the tumor, known as tumor-associated neutrophils (TANs). There has been a surge of interest in researching the eminent heterogeneity and plasticity of TANs in recent years, and scholars increasingly cotton on to the multifaceted functions of TANs so that strenuous endeavors have been devoted to enunciating their potential as therapeutic targets. Yet it remains much left to translate TAN-targeted immunotherapies into clinical practice. Therefore, there is great significance to comprehensively appraise the research status, focal point, and evolution trend of TAN by using bibliometric analysis.Publications related to TAN research from 2000 to 2024 are extracted from the Web of Science Core Collection. Bibliometric analysis and visualization were performed by tools encompassing Microsoft Excel, VOSviewer, CiteSpace, R-bibliometrix, and so on.The bibliometric analysis included a total of 788 publications authored by 5291 scholars affiliated with 1000 institutions across 58 countries/regions, with relevant articles published in 324 journals. Despite China's maximum quantity of publications and top 10 institutions, the United States is the leading country with the most high-quality publications and is also the global cooperation center. FRONTIERS IN IMMUNOLOGY published the most papers, whereas CANCER RESEARCH is the highest co-cited journal. Israeli professor Fridlender, Zvi G. is the founder, pioneer, and cultivator with the highest citation counts and H-index in the TAN area. Our analysis prefigures the future trajectories: TAN heterogeneity, neutrophil extracellular trap, the crosstalk between TANs and immunocytes, and immunotherapy will likely be the focus of future research.A comprehensive bibliometric and visual analysis is first performed to map the current landscape and intellectual structure of TAN, which proffers fresh perspectives for further research. The accurate identification of distinct TAN subpopulations and the precise targeting of key pro-tumor/anti-tumor subpopulations hold immense potential to develop into a TAN-targeted immunotherapy.Copyright © 2024 Xiao, Feng, Aini, Zhao, Ding and Gao.