旨在探讨乳腺癌幸存者不良童年经历 (ACE) 的发生率以及与长期治疗相关后遗症的潜在关联。招募了诊断后三年或以上且治疗完全缓解的说英语的乳腺癌幸存者 (N = 120)在计划的生存诊所就诊之前。这项横断面观察可行性研究的参与者对焦虑、抑郁、疲劳、睡眠障碍、认知问题、复原力和 ACE（18 岁之前经历的）进行了评分。分析血液样本的炎症和表观遗传生物标志物。ACE 评估是可行的。较高的 ACE 分数与较严重的疲劳、焦虑和抑郁以及较低的认知功能相关 (p < 0.05)。复原力与认知功能呈正相关，与疲劳、焦虑和抑郁呈负相关。有证据表明 ACE 对乳腺癌女性长期治疗相关后遗症有影响。肿瘤科护士应考虑将 ACE 评估纳入接受生存护理的女性的工作流程中。

To explore the incidence of adverse childhood experiences (ACEs) in breast cancer survivors and potential associations with long-term treatment-related sequelae.English-speaking breast cancer survivors three or more years from diagnosis with complete treatment response (N = 120) were recruited prior to scheduled survivorship clinic visits.Participants in this cross-sectional observational feasibility study rated anxiety, depression, fatigue, sleep disturbance, cognitive issues, resilience, and ACEs (experienced prior to age 18 years). Blood samples were analyzed for inflammatory and epigenetic biomarkers.ACEs assessment was feasible. Higher ACE scores correlated with greater fatigue, anxiety, and depression, and with lower cognitive function (p < 0.05). Resilience was positively associated with cognitive function and negatively associated with fatigue, anxiety, and depression.There is evidence for the impact of ACEs on long-term treatment-related sequelae in women with breast cancer. Oncology nurses should consider incorporating ACEs assessment into the workflow for women receiving survivorship care.