ROS的合理利用是治疗感染伤口的关键。外源ROS可以破坏细菌结构，快速杀死细菌，抑制继发感染。然而，伤口处过量的ROS会引起继发性炎症反应。急性感染会增加内源性 ROS，从而加剧这种损害，使 ROS 稳态的维持复杂化。因此，调节伤口中ROS产生和清除的平衡已成为伤口治疗的一种有前景的策略。传统的ROS平衡平台大多基于“全为一”的功能叠加策略，缺乏自适应性和集成性。为了颠覆这一传统策略，本研究提出了一种“一劳永逸”的自适应综合光动力疗法（PDT）-抗氧化模型来主动调节ROS平衡。嵌入 Se 修饰的二氧化铈纳米粒子 (Gel-HA-Se@CeO2 NPs) 的明胶透明质酸水凝胶设计用于治疗感染伤口。 Se@CeO2 NPs 既可用作纳米酶又可用作光敏剂（PS）。作为纳米酶，它们表现出过氧化氢酶和超氧化物歧化酶活性，将过氧化氢和超氧阴离子转化为氧气。作为PS，它在近红外辐射下与氧协同作用，快速产生单线态氧。此外，Se 修饰通过破坏细菌抗氧化系统来增强 PDT 效果。体外和体内实验表明，ROS平衡平台将M1型巨噬细胞极化为M2型巨噬细胞，将伤口微环境从促炎改变为促愈合。 RNA测序显示，这种水凝胶通过激活PI3K/AKT通路和增加VEGF分泌来加速伤口血管网络的重建。这种策略被认为不仅有益于感染伤口，而且也有利于治疗涉及调节的其他疾病活性氧，例如肿瘤和细菌感染。© 2024 Wiley‐VCH GmbH。

The rational utilization of ROS is key to treating infected wounds. Exogenous ROS can destroy bacterial structures, quickly kill bacteria, and inhibit secondary infections. However, excess ROS at the wound will cause a secondary inflammatory response. Acute infections exacerbate this damage by increasing endogenous ROS, complicating the maintenance of ROS homeostasis. Therefore, regulating the balance of ROS production and scavenging in wounds has emerged as a promising strategy for wound treatment. Conventional ROS balancing platforms are mostly based on the " all for one" strategy of functional superposition and lack self-adaptability and integration. To subvert this conventional strategy, this study proposes a "one for all" self-adaptive integrated photodynamic therapy (PDT)-antioxidant model to actively regulate the ROS balance. A gelatin-hyaluronic acid hydrogel embedded with Se-modified cerium dioxide nanoparticles (Gel-HA-Se@CeO2 NPs) is designed for treating infected wounds. The Se@CeO2 NPs serve both as nanoenzymes and photosensitizers(PS). As nanoenzymes, they exhibit catalase and superoxide dismutase activities, converting hydrogen peroxide and superoxide anions into oxygen. As a PS, it synergizes with oxygen under NIR irradiation to rapidly produce singlet oxygen. Additionally, Se modification enhances the PDT effects by disrupting bacterial antioxidant systems. In vitro and in vivo experiments revealed that the ROS balance platform polarizes M1-type macrophages to M2-type macrophages, altering the wound microenvironment from proinflammatory to prohealing. RNA sequencing revealed that this hydrogel accelerated the reconstruction of the vascular network of the wound by activating the PI3K/AKT pathway and increasing VEGF secretion.This strategy is believed to be beneficial not only for infected wounds but also for treating other conditions that involve the regulation of reactive oxygen species, such as tumors and bacterial infections.© 2024 Wiley‐VCH GmbH.