玫瑰 (Rosa rugosa Thunb)。是我国历史悠久的一种药食同源的中药。 R. rugosa Thunb 中的总黄酮。 (TFR)具有抗氧化、抗肿瘤、抗抑郁、抗菌等活性，可有效预防和治疗心血管、高血糖、高血脂等疾病。然而，很少有研究关注 TFR 分析，也没有发表全面的综述。本文在前人研究的基础上，系统综述了TFR的提取纯化工艺、化学成分、生物活性、毒理学以及在食品中的应用，为进一步的研究和开发提供理论基础和研究方向。从 R. rugosa Thunb 中总共分离出了 102 种不同的黄酮类化合物。进一步的药理活性和化学分析研究将有助于 R.rugosa Thunb 中 TFR 产品的开发。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Rosa rugosa Thunb. is a kind of traditional Chinese medicine with homology of medicine and food in China for a long history. The total flavonoids from R. rugosa Thunb. (TFR), possessing antioxidant, anti-tumor, antidepressant, and antibacterial activities, can effectively prevent and treat cardiovascular, hyperglycemia, hyperlipidemia, and other diseases. However, few studies have focused on TFR analyses and no comprehensive review has yet been published. In order to provide a theoretical foundation and research direction for further study and development, this paper methodically reviewed the extraction and purification procedure, chemical composition, biological activity, toxicology, and application in food of TFR on the basis of previous research. A total of 102 distinct flavonoids have been isolated from R. rugosa Thunb. Further pharmacological activities and chemical analyses research will contribute to the development of TFR products in R. rugosa Thunb.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.