由于其晚期诊断和有限的治疗选择，卵巢癌仍然是肿瘤学中的一个巨大挑战。最近的研究揭示了卵巢肿瘤内聚糖多样性与免疫微环境之间复杂的相互作用，为潜在的治疗策略提供了新的线索。本综述旨在研究聚糖在卵巢癌中的复杂作用及其对免疫反应的影响。聚糖是装饰细胞表面和分泌蛋白的复杂糖分子，已成为卵巢癌免疫监视的关键调节因子。异常的糖基化模式可以通过保护肿瘤细胞免受免疫识别来促进免疫逃避，从而促进疾病进展。相反，某些聚糖结构可以调节免疫反应，从而产生抗肿瘤免疫或免疫耐受。了解卵巢癌中聚糖多样性与免疫相互作用之间的复杂关系有望开发创新的治疗方法。针对聚糖介导的免疫逃避的免疫疗法，例如基于聚糖的疫苗或检查点抑制剂，正在研究中。此外，聚糖分析可以作为患者分层和治疗选择的诊断工具。本综述强调了聚糖多样性在卵巢癌中日益显现的重要性，强调了揭示免疫相互作用和推进针对这种毁灭性疾病的定制治疗前景的潜力。© 2024。作者。

Ovarian cancer remains a formidable challenge in oncology due to its late-stage diagnosis and limited treatment options. Recent research has revealed the intricate interplay between glycan diversity and the immune microenvironment within ovarian tumors, shedding new light on potential therapeutic strategies. This review seeks to investigate the complex role of glycans in ovarian cancer and their impact on the immune response. Glycans, complex sugar molecules decorating cell surfaces and secreted proteins, have emerged as key regulators of immune surveillance in ovarian cancer. Aberrant glycosylation patterns can promote immune evasion by shielding tumor cells from immune recognition, enabling disease progression. Conversely, certain glycan structures can modulate the immune response, leading to either antitumor immunity or immune tolerance. Understanding the intricate relationship between glycan diversity and immune interactions in ovarian cancer holds promise for the development of innovative therapeutic approaches. Immunotherapies that target glycan-mediated immune evasion, such as glycan-based vaccines or checkpoint inhibitors, are under investigation. Additionally, glycan profiling may serve as a diagnostic tool for patient stratification and treatment selection. This review underscores the emerging importance of glycan diversity in ovarian cancer, emphasizing the potential for unraveling immune interplay and advancing tailored therapeutic prospects for this devastating disease.© 2024. The Author(s).