新辅助化疗 (NAC) 后的病理完全缓解 (pCR) 和肿瘤浸润淋巴细胞 (TIL) 的百分比是早期乳腺癌 (BC) 的既定预后生物标志物。虽然运动训练在整个 BC 旅程中作为支持性护理是有效的，但其对 NAC 疗效的影响尚不清楚。本研究旨在调查监督运动训练计划 (SETP) 对接受 NAC 的 BC 妇女的 pCR 和 TIL 的影响。对接受 NAC 治疗的 BC 患者亚组进行回顾性探索性分析，该亚组包括随机分配到 STEP 和对照组的临床试验。终点为 pCR、活检和基质 TIL。 纳入 64 名参与者，平均年龄为 50.3±10.1 岁，主要为 II 期和 III 期疾病 (n = 58, 90.6%)、HER2  (n = 23, 35.9%) ），或三阴性（n = 19，29.7%）肿瘤。 STEP 组和对照组的 pCR 分别为 56.7% 和 55.9% (p = 0.950)。在 STEP 组中，活检和肿瘤部位的中位 TIL 分别为 5.0 (0.0-80.0) 和 5.0 (5.0-30.0)，而在对照组中，分别为 5.0 (0.0-90.0) 和 0.0 (0.0-30.0)。活检和肿瘤部位的 TIL 差异分别为 0.04（置信区间 (CI 95%) - 13.6、13.7；p = 0.995）和 - 4.3（CI 95% - 11.5、2.9；(p = 0.233）。在活检的 TIL 方面，各组之间没有发现统计学上的显着差异。然而，肿瘤部位的 TIL 水平略高与 SETP 臂相关。在 pCR 和 TIL 方面，组内和组间均未发现差异，这可能存在相关性。保证未来充分有力的研究。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) and the percentage of tumor-infiltrating lymphocytes (TILs) are established prognostic biomarkers in early breast cancer (BC). While exercise training is effective as supportive care throughout the BC journey, its impact on the efficacy of NAC is unknown. This study aims to investigate the influence of a supervised exercise training program (SETP) on pCR and TILs in BC women undergoing NAC.Retrospective exploratory analysis of the subgroup of BC patients treated with NAC included in a clinical trial randomizing to STEP and control arm. Endpoints were pCR, biopsy, and stromal TILs.Sixty-four participants were included, with a mean age of 50.3 ± 10.1 years, predominantly stage II and III disease (n = 58, 90.6%), HER2 + (n = 23, 35.9%), or triple-negative (n = 19, 29.7%) tumors. pCR was achieved in 56.7% and 55.9% in the STEP and control arm (p = 0.950). In the STEP arm, median TILs were 5.0 (0.0-80.0) and 5.0 (5.0-30.0), while in the control arm, 5.0 (0.0-90.0) and 0.0 (0.0-30.0) for biopsy and tumor site, respectively. The difference in TILs between arms was 0.04 (confidence interval (CI 95%) - 13.6, 13.7; p = 0.995) and - 4.3 (CI 95% - 11.5, 2.9; (p = 0.233) for biopsy and tumor site, respectively. No statistically significant difference was discerned between the groups concerning TILs of the biopsy. However, a marginally higher TIL level at the tumor site was associated with the SETP arm.No differences were discerned within and between groups on both pCR and TILs, in possible relation to the exploratory nature of the analysis. Future adequately powered research is warranted.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.