软组织血管纤维瘤（AFST）是一种罕见的良性纤维瘤，最近被纳入 2020 年 WHO 软组织和骨肿瘤分类。目前，关于AFST的报道有限，病理学家对其临床和病理特征缺乏足够的了解。目前关于宫颈区域 AFST 的文献很少。我们报道了一名 49 岁女性患者，她因阴道流血和疲劳而入院急诊治疗。超声检查示一63 × 27mm的低回声肿块，从宫颈口延伸至宫颈外口，血常规血红蛋白58.0g/L。组织呈淡黄色粘液样，组织边界清晰，下有纤维包膜。显微镜。 HE染色显示成纤维细胞呈梭形，形态一致，薄壁分支小血管，血管扩张。细胞丰富的区域和细胞稀疏的区域交替分布并逐渐迁移。免疫组化分析显示肿瘤中 P53、结蛋白、孕激素受体、雌激素受体、上皮膜抗原、波形蛋白、CD68、CD163 阳性表达，P16、S-100、平滑肌肌动蛋白、CD117、CD10、STAT-6 阴性表达。 CD34在肿瘤细胞中呈阴性，但在血管内皮细胞中呈阳性。 Ki-67指数值为5%。病理检查证实宫颈软组织纤维血管瘤。输注3单位浓缩红细胞后进行紧急宫腔镜手术。对宫颈肿块进行了局部切除。1个月的随访超声显示宫颈管内未见异常肿块，且至今未见复发迹象。宫颈软组织血管纤维瘤是一种罕见的良性肿瘤。临床表现良好，局部复发极少，无明显转移潜力。治疗主要涉及局部切除，重点是实现阴性手术切缘。通过介绍此病例，我们旨在提高病理学家识别子宫肿瘤和防止误诊的诊断和鉴别诊断能力。版权所有 © 2024 作者。由 Wolters Kluwer Health, Inc. 出版

Angiofibroma of soft tissue (AFST) is a rare benign fibrous tumor recently included in the 2020 WHO classification of soft tissue and bone tumors. Currently, there are limited reports on AFST, and pathologists lack sufficient understanding of its clinical and pathological characteristics. There is scarce literature available on AFST in the cervical region.We presented a case of a 49-year-old woman who was admitted to our hospital for emergency treatment due to vaginal bleeding and fatigue. Ultrasound revealed a 63 × 27 mm hypoechoic mass extending from the cervical opening to the external opening, with a hemoglobin level of 58.0 g/L on blood routine.The tissue exhibited a pale-yellow mucinous appearance with distinct tissue boundaries and a fibrous capsule under a microscope. HE staining revealed spindle-shaped fibroblast-like cells with a consistent morphology, thin-walled branching small blood vessels, and dilated blood vessels. Regions with abundant cells and areas with sparse cells were alternately distributed and migrated gradually. Immunohistochemical analysis indicated positive expression of P53, desmin, progesterone receptor, estrogen receptor, epithelial membrane antigen, vimentin, CD68, CD163 in the tumor, but negative expression of P16, S-100, smooth muscle actin, CD117, CD10, STAT-6. CD34 was negative in the tumor cells but positive in the vascular endothelium. The Ki-67 index value was 5%. Pathological examination confirmed a soft tissue angiofibroma of the cervix.Emergency hysteroscopic surgery was performed following infusion of 3 units of packed red blood cells. A local excision of the cervical mass was performed.A 1-month follow-up ultrasound showed no abnormal mass in the cervical canal, and there have been no signs of recurrence to date.Cervical angiofibroma of soft tissue is a rare tumor with a benign clinical manifestation, minimal local recurrence, and no significant metastatic potential. Treatment primarily involves local resection with a focus on achieving negative surgical margins. By presenting this case, we aim to enhance the diagnostic and differential diagnostic capabilities of pathologists in identifying uterine tumors and preventing misdiagnosis.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.