黄斑是视网膜中一个虽小但非常重要的区域，对于健康的视力至关重要。全球大约 8.7% 的失明是由年龄相关性黄斑变性引起的，而且受影响的人数正在迅速增加。与年龄相关的黄斑变性通常是由氧化应激和过度炎症引起的，这些炎症会损害黄斑中的视网膜色素上皮细胞。姜黄素是一种有效的抗氧化剂和抗炎类胡萝卜素，但由于食品科学中的低相容性和稳定性问题而受到阻碍。创新地，这项研究利用牛奶来源的外​​泌体作为一种新颖的递送方法，产生姜黄素注入系统（姜黄素@外泌体），以提高其生物相容性和稳定性。这种融合不仅抑制了过多的活性氧，还中和了细胞模型中 H2O2 诱导的线粒体破坏。它使视网膜色素上皮细胞恢复活力，在体外将其功能恢复到接近基线的水平。姜黄素@外泌体在抑制碘酸钠诱导的促炎细胞因子肿瘤坏死因子-α和白细胞介素-1β方面表现出色。这项研究表明姜黄素@外泌体有望成为治疗以氧化和炎症为特征的视网膜疾病的干预措施。版权所有 © 2024 Elsevier B.V. 保留所有权利。

The macula, a small but highly important area in the retina, is crucial for healthy vision. Age-related macular degeneration is responsible for approximately 8.7 % of blindness worldwide, and affected individuals are burgeoning. The age-related macular degeneration is often triggered by oxidative stress and excessive inflammation that damage the retinal pigment epithelial cells in the macula. Curcumin, a potent antioxidant and anti-inflammatory carotenoid, is hampered by low compatibility and stability issues in food science. Innovatively, this study harnessed milk-derived exosomes as a novel delivery method yielding a curcumin-infused system (curcumin@exosome) to increase its biocompatibility and stability. This fusion not only curbed excessive reactive oxygen species but also neutralized H2O2-induced mitochondrial disruption in cellular models. It revitalized retinal pigment epithelial cells, reverting their function near to baseline in vitro. The curcumin@exosome outshined in subduing pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β induced by sodium iodate. This study illuminates that the curcumin@exosome is promise as a therapeutic intervention for retinal ailments marked by oxidative and inflammatory distress.Copyright © 2024 Elsevier B.V. All rights reserved.