这项探索性研究调查了南非宫颈癌患者炎症与血栓形成之间的可能关系，强调了改进血栓形成风险分析的必要性。血栓弹力图 (TEG) 用于评估一小群人的贫血小板血浆 (PPP) 的凝血参数晚期（III 期和 IV 期）宫颈癌患者 (n = 19) 和健康对照者 (n = 15)。评估的参数包括凝血时间、凝块形成速度和凝块强度。 Luminex Multiplex 检测用于测量干扰素-γ (IFN-γ)、白细胞介素-1β (IL-1β)、IL-6、血管内皮生长因子-A (VEGF-A) 和肿瘤坏死因子-α (TNF) -α) 在 PPP 中。还评估了血液学特征。宫颈癌患者表现出凝血时间显着缩短 (p = 0.0044) 和凝血强度增加 (p = 0.0003)，表明凝血功能增强。 IL-1β 显着升高 (p = 0.0200)，与炎症环境一致。观察到较高的淋巴细胞、中性粒细胞和血小板计数（分别为 p = 0.0162、0.0420 和 0.0374），表明可能存在血栓前状态。这些发现表明宫颈癌患者的炎症和血栓形成之间存在潜在联系。然而，由于这项研究的样本量较小且具有探索性，这些因素之间的直接关系尚未明确建立，并且仍处于推测阶段。血栓风险分析仍可能为患者管理提供价值，但需要进一步调查来证实这些初步观察结果。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

This exploratory study investigates the possible relationship between inflammation and thrombosis in cervical cancer patients in South Africa, highlighting the need for improved thrombotic risk profiling.Thromboelastography (TEG) was used to assess coagulation parameters in platelet-poor plasma (PPP) from a small cohort of late-stage (III and IV) cervical cancer patients (n = 19) and healthy controls (n = 15). Parameters assessed included clotting time, clot formation speed, and clot strength. A Luminex Multiplex assay was used to measure interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, vascular endothelial growth factor-A (VEGF-A), and tumour necrosis factor-α (TNF-α) in PPP. Haematological profiles were also evaluated.Cervical cancer patients displayed a significantly shortened clotting time (p = 0.0044) and increased clot strength (p = 0.0003), suggesting enhanced coagulation. IL-1β was notably elevated (p = 0.0200), consistent with an inflammatory environment. Higher lymphocyte, neutrophil, and platelet counts (p = 0.0162, 0.0420, and 0.0374, respectively) were observed, indicating a possible prothrombotic state.These findings suggest a potential link between inflammation and thrombosis in cervical cancer patients. However, due to this study's small sample size and exploratory nature, direct relationships between these factors have yet to be definitively established and remain speculative. Thrombotic risk profiling may still offer value in managing patients, but further investigation is required to confirm these preliminary observations.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.