舌唾液癌代表着治疗挑战，因为其根治性切除尤其具有破坏性。我们的目的是研究晚期舌唾液癌的肿瘤学和功能结果。这项回顾性多中心研究基于法国罕见头颈癌国家网络 (REFCOR)，纳入了所有患有 T3-T4 唾液癌的患者舌头，于 2009 年 1 月至 2018 年 12 月期间诊断。总共纳入 47 名患者，其中 44.7% 接受了手术。组织学主要为腺样囊性癌（61.7%），其次是其他腺癌（27.7%）和粘液表皮样癌（10.6%）。中位随访时间为 63.9 个月。在多变量分析中，手术与更好的无复发生存率（HR = 0.23，95% CI [0.09;0.55]）和局部/区域无复发生存率（HR = 0.31，95% CI [0.10;0.95]）显着相关。随访结束时，手术组远处转移率为61.9%，非手术组为57.7%。无远处转移生存率为 54.9% [38.3;68.7]，两组之间没有统计学差异。确定性胃造口术的发生率相似，但最后一次随访时正常口服饮食的发生率在手术组中似乎更高（38.1% vs 15.4%）。该人群的根治性手术主要旨在改善局部/区域控制，这可能导致更好的长期吞咽功能。这些肿瘤中约一半可能在初次就诊时与隐匿性远处转移有关。需要更多的研究来确定术后放疗和非手术治疗同时进行 CRT 的作用。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Salivary carcinomas of the tongue represent a therapeutic challenge as their radical excision is particularly mutilating. We aimed to study the oncologic and functional outcomes of advanced stages salivary carcinomas of the tongue.This retrospective multicentric study, based on the French national network on rare head and neck cancers (REFCOR), included all patients with a T3-T4 salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018.In total, 47 patients were included, of which 44.7 % underwent surgery. Histologies were mostly adenoid cystic carcinomas (61.7 %), followed by other adenocarcinomas (27.7 %) and mucoepidermoid carcinomas (10.6 %). Median follow-up duration was 63.9 months. In multivariable analysis, surgery was significantly associated with better Recurrence-Free Survival (HR = 0.23, 95 %CI [0.09;0.55]) and Local/Regional Recurrence-Free Survival (HR = 0.31, 95 %CI [0.10;0.95]). The rate of distant metastasis at the end of follow-up was 61.9 % in the surgical group and 57.7 % in the non-surgical group. The Distant Metastasis Free Survival was 54.9 % [38.3;68.7], without statistical difference between both groups. There were similar rates of definitive gastrostomies but the rate of normal oral diet at the last follow-up seemed higher in the surgery group (38.1 % vs 15.4 %).Radical surgery in that population mainly aims to improve local/regional control, which may result in better long-term swallowing functions. About half of these tumors may be associated with occult distant metastasis at initial presentation. More studies are warranted to establish the role of postoperative RT and non-surgical treatment with concurrent CRT.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.