使用电辅助微针 (MN) 系统的透皮给药 (TDD) 已成为传统给药途径的一种有前途的替代方案。这篇综述探讨了该技术在各种治疗应用中的最新进展。将离子电渗疗法 (IP) 和电穿孔 (EP) 与 MN 技术相结合，在改善各种病症的治疗效果方面显示出巨大的潜力。研究证明它们在增强疫苗和 DNA 递送、改善糖尿病管理以及提高皮肤病学应用功效方面的有效性。该技术还在提供非甾体抗炎药 (NSAID)、治疗多发性硬化症以及推进肥胖和癌症治疗方面展现出前景。这些系统可改善药物渗透、靶向递送并增强治疗效果。尽管安全问题和技术限制等挑战仍然存在，但正在进行的研究重点是优化这些系统以实现更广泛的临床应用。 TDD 中的电辅助 MN 技术的未来似乎充满希望，在个性化医疗、智能监测系统和扩展的治疗应用方面具有潜在的进步。© 2024。作者。

Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems has emerged as a promising alternative to traditional drug administration routes. This review explores recent advancements in this technology across various therapeutic applications. Integrating iontophoresis (IP) and electroporation (EP) with MN technology has shown significant potential in improving treatment outcomes for various conditions. Studies demonstrate their effectiveness in enhancing vaccine and DNA delivery, improving diabetes management, and increasing efficacy in dermatological applications. The technology has also exhibited promise in delivering nonsteroidal anti-inflammatory drugs (NSAIDs), treating multiple sclerosis, and advancing obesity and cancer therapy. These systems offer improved drug permeation, targeted delivery, and enhanced therapeutic effects. While challenges remain, including safety concerns and technological limitations, ongoing research focuses on optimizing these systems for broader clinical applications. The future of electrically assisted MN technologies in TDD appears promising, with potential advancements in personalized medicine, smart monitoring systems, and expanded therapeutic applications.© 2024. The Author(s).