电离子导入和电穿孔辅助微针：在经皮药物递送中的进展与治疗潜能
Iontophoresis and electroporation-assisted microneedles: advancements and therapeutic potentials in transdermal drug delivery
DOI 原文链接
用sci-hub下载
如无法下载，请从 Sci-Hub 选择可用站点尝试。
影响因子:5.5
分区:医学3区 / 医学：研究与实验3区 药学3区
发表日期:2025 Jun
作者:
Mehrnaz Abbasi, Braeden Heath
DOI:
10.1007/s13346-024-01722-7
摘要
利用电辅助微针（MN）系统进行经皮药物递送（TDD）已成为传统药物给药途径的有前景的替代方案。本文综述了该技术在多种治疗应用中的最新进展。结合电离子导入（IP）和电穿孔（EP）技术的微针系统，在改善疫苗和DNA递送、糖尿病管理以及皮肤病治疗等方面展现出显著潜力。研究表明，这些系统能增强药物渗透、实现靶向递送，并提升治疗效果。该技术还在非甾体抗炎药（NSAIDs）递送、多发性硬化症治疗、肥胖和癌症治疗中表现出良好的应用前景。尽管存在安全性和技术限制等挑战，但持续的研究致力于优化这些系统的临床应用。未来，电辅助微针技术在TDD中的发展令人期待，有望推动个性化医疗、智能监测系统及更广泛的治疗领域。
Abstract
Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems has emerged as a promising alternative to traditional drug administration routes. This review explores recent advancements in this technology across various therapeutic applications. Integrating iontophoresis (IP) and electroporation (EP) with MN technology has shown significant potential in improving treatment outcomes for various conditions. Studies demonstrate their effectiveness in enhancing vaccine and DNA delivery, improving diabetes management, and increasing efficacy in dermatological applications. The technology has also exhibited promise in delivering nonsteroidal anti-inflammatory drugs (NSAIDs), treating multiple sclerosis, and advancing obesity and cancer therapy. These systems offer improved drug permeation, targeted delivery, and enhanced therapeutic effects. While challenges remain, including safety concerns and technological limitations, ongoing research focuses on optimizing these systems for broader clinical applications. The future of electrically assisted MN technologies in TDD appears promising, with potential advancements in personalized medicine, smart monitoring systems, and expanded therapeutic applications.