电导电离和电穿孔辅助微针：在经皮药物输送中的进展与治疗潜力
Iontophoresis and electroporation-assisted microneedles: advancements and therapeutic potentials in transdermal drug delivery
影响因子:5.50000
分区:医学3区 / 医学：研究与实验3区 药学3区
发表日期:2025 Jun
作者:
Mehrnaz Abbasi, Braeden Heath
摘要
利用电辅助微针（MN）系统的经皮药物输送（TDD）已成为传统药物给药途径的有前景替代方案。本文综述了该技术在多种治疗应用中的最新进展。将电导（IP）和电穿孔（EP）与微针技术结合，显示出在改善疫苗和DNA递送、糖尿病管理以及皮肤病学应用中的显著潜力。研究表明，该技术能增强药物穿透性、靶向递送和提高治疗效果。尽管仍面临安全性和技术限制的挑战，持续的研究正致力于优化这些系统以拓展其临床应用。电辅助微针技术的未来在个性化医疗、智能监测系统和更广泛的治疗领域具有巨大潜力。
Abstract
Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems has emerged as a promising alternative to traditional drug administration routes. This review explores recent advancements in this technology across various therapeutic applications. Integrating iontophoresis (IP) and electroporation (EP) with MN technology has shown significant potential in improving treatment outcomes for various conditions. Studies demonstrate their effectiveness in enhancing vaccine and DNA delivery, improving diabetes management, and increasing efficacy in dermatological applications. The technology has also exhibited promise in delivering nonsteroidal anti-inflammatory drugs (NSAIDs), treating multiple sclerosis, and advancing obesity and cancer therapy. These systems offer improved drug permeation, targeted delivery, and enhanced therapeutic effects. While challenges remain, including safety concerns and technological limitations, ongoing research focuses on optimizing these systems for broader clinical applications. The future of electrically assisted MN technologies in TDD appears promising, with potential advancements in personalized medicine, smart monitoring systems, and expanded therapeutic applications.