在前列腺活检和根治性前列腺切除术 (RP) 标本中，前列腺癌的导管内癌 (IDC) 和筛状模式 (Crib) 越来越被认为是预后不良的独立预测因素。我们项目的目的是评估假阴性活检的影响这两个特征对肿瘤学结果的影响。该研究纳入了 2015 年 1 月至 2022 年 12 月期间接受 RP 的患者。使用多变量 Cox 比例风险模型检查生化失败的预测因素。在 836 名接受 RP 的患者中，233 名 (27.9%) 患有 Crib，125 名 (15.0%) 前列腺活检时患有 IDC，其中 71 名 (8.5%) 患者患有 IDC。 IDC 和 Crib。关于活检时的 IDC/Crib 状态，217 名患者 (26%) 活检呈假阴性，332 名患者 (39.7%) 活检呈真阴性，256 名患者 (30.6%) 活检呈真阳性，24 名患者 (3.7%) 活检呈真阳性。 ）对于任一模式均表现出假阳性活检。在比较 IDC/Crib 的假阴性、假阳性、真阴性和真阳性活检时，我们发现 IDC/Crib 假阴性活检的患者与 IDC/Crib 真阴性活检的患者披露晚期病理分期（≥pT3）的比率是 IDC/Crib 活检真阴性患者的两倍：分别为 56.8% 和 28.1%（p<0.001）。在多变量 Cox 分析中，RP 前记录 PSA（风险比 [HR] 2.07，95% CI 1.53-2.82；p < 0.001），活检时阳性核心百分比较高（ ≥ 33%）（HR 1.68，95% CI 1.07） -2.63；p = 0.024）和 IDC/Crib 假阴性活检（HR 2.14，95% CI 1.41-3.25；p < 0.001）均与 BCR 风险增加显着相关。IDC 假阴性活检与真正的阴性活检相比，/Crib 与较高的 BCR 风险和晚期病理阶段独立相关。© 2024。作者获得 Springer Nature Limited 的独家许可。

Intraductal carcinoma (IDC) and cribriform pattern (Crib) of prostate cancer are increasingly recognized as independent prognosticators of poor outcome, both in prostate biopsies and radical prostatectomy (RP) specimens.The aim of our project is to assess the impact of false negative biopsies for these two characteristics on oncological outcomes.Patients who underwent RP between January 2015 and December 2022 were included in the study. Predictors of Biochemical Failure were examined using a multivariate Cox proportional hazards model.Among the 836 patients who underwent RP, 233 (27.9%) had Crib, and 125 (15.0%) had IDC on prostate biopsy, with 71 (8.5%) patients having both IDC and Crib. Concerning IDC/Crib status at biopsy, 217 (26%) patients had a false-negative biopsy, 332 (39.7%) had a true-negative biopsy, 256 (30.6%) showed a true-positive biopsy, and 24 (3.7%) exhibited a false-positive biopsy, with respect to either pattern. When comparing false-negative, false-positive, true-negative and true-positive biopsies for IDC/Crib, we found that patients with a false-negative biopsy for IDC/Crib versus those with a true-negative biopsy for IDC/Crib disclosed a rate of advanced pathological stage (≥pT3) which was twice that of patients with a true-negative biopsy for IDC/Crib: 56.8% versus 28.1%, respectively (p < 0.001). On multivariate Cox analysis, log PSA before RP (hazard ratio [HR] 2.07, 95% CI 1.53-2.82; p < 0.001), a higher percentage of positive cores at biopsy ( ≥ 33%) (HR 1.68, 95% CI 1.07-2.63; p = 0.024), and false negative biopsy for IDC/Crib (HR 2.14, 95% CI 1.41-3.25; p < 0.001), were each significantly associated with an increased risk of BCR.A false-negative biopsy for IDC/Crib is independently associated with higher risk of BCR and advanced pathological stage compared to a true negative biopsy.© 2024. The Author(s), under exclusive licence to Springer Nature Limited.