腺苷（ADO）是一种天然存在的核苷，主要通过细胞外三磷酸腺苷的水解合成。在肿瘤微环境中，ADO 水平大幅增加，导致免疫反应受到抑制。纳米系统为将药物精确递送至肿瘤病灶提供了一种有前途的方法。在这篇综述中，我们概述了目前在肿瘤免疫治疗中调节腺苷信号传导的纳米系统开发的研究进展。这些纳米系统旨在靶向腺苷水解蛋白，增加腺苷分解，拮抗腺苷受体。根据文献综述，腺苷在肿瘤免疫治疗中具有巨大潜力，纳米药物递送系统在肿瘤靶向治疗中具有巨大的应用前景。由于其优越的特性，不久的将来。

Adenosine (ADO) is a naturally occurring nucleoside primarily synthesized through the hydrolysis of extracellular adenosine triphosphate. Within the tumor microenvironment, ADO levels substantially increase, resulting in suppressed immune responses.Nanosystems offer a promising approach for precise drug delivery to tumor lesions. In this review, we provide an overview of the current research progress in the development of nanosystems that modulate adenosine signaling for tumor immunotherapy. These nanosystems are designed to target adenosine-hydrolyzing proteins, increase adenosine decomposition, and antagonize adenosine receptors.Based on the literature review, adenosine has great potential in tumor immunotherapy, and nano-drug delivery system has great application prospects in targeted cancer therapy in the near future due to its superior characteristics.